Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung

Jun Yang, Parrisa Solaimani, Hua Dong, Bruce Hammock, Oliver Hankinson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We previously reported that 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) increased the levels of several cytochrome P450 metabolites of the omega-6 polyunsaturated fatty acids (PUFAs), arachidonic acid (ARA) and linoleic acid in the serum, liver, lung and spleen of C57BL/6 mice in an aryl hydrocarbon receptor (AHR)-dependent fashion. These increases correlated with increased levels of CYP1A1, CYP1A2 and/or CYP1B1. In the current study, we measured 77 oxylipins, including 59 that we had not measured previously, and demonstrate that TCDD also markedly increases the levels of many epoxide and diol metabolites of the omega-3 PUFAs, a-linolenic acid, eicosapentaenoic acid (EPA) and docasahexaenoic acid (DHA) in these mice. Since these epoxide metabolites have been reported to have opposite effects on angiogenesis, tumor growth and tumor metastasis compared with the equivalent metabolites of omega-6 PUFA, these observations have important implications with regard to the potential involvement of the cytochrome P450 metabolites of PUFAs in mediating the biological effects of TCDD and other agonists of AHR.

Original languageEnglish (US)
Pages (from-to)833-836
Number of pages4
JournalJournal of Toxicological Sciences
Volume38
Issue number6
DOIs
StatePublished - 2013

Fingerprint

Omega-3 Fatty Acids
Metabolites
Unsaturated Fatty Acids
Liver
Cytochrome P-450 Enzyme System
Omega-6 Fatty Acids
Lung
Epoxy Compounds
Aryl Hydrocarbon Receptors
Oxylipins
Tumors
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
alpha-Linolenic Acid
Eicosapentaenoic Acid
Linoleic Acid
Inbred C57BL Mouse
Arachidonic Acid
Neoplasms
Spleen

Keywords

  • AHR
  • Dioxin
  • Eicosanoids
  • Omega-3
  • Oxylipins
  • TCDD

ASJC Scopus subject areas

  • Toxicology

Cite this

Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. / Yang, Jun; Solaimani, Parrisa; Dong, Hua; Hammock, Bruce; Hankinson, Oliver.

In: Journal of Toxicological Sciences, Vol. 38, No. 6, 2013, p. 833-836.

Research output: Contribution to journalArticle

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