Treatment of Locally Advanced Non–Small Cell Lung Cancer

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Locally advanced non–small cell lung cancer is a heterogeneous disease with typically poor outcomes. Select patients may benefit from the integration of surgery, whereas patients with bulky, multistation, or contralateral (N3) mediastinal involvement are managed with definitive chemoradiation. Attempts to improve outcomes through induction, consolidation, or maintenance chemotherapy or radiation dose escalation have not demonstrated a survival benefit. Current research efforts focus on the integration of novel systemic agents that exploit tumor-specific driver mutations, augment antitumor immune response, or enhance radiation sensitivity.

Original languageEnglish (US)
Pages (from-to)45-57
Number of pages13
JournalHematology/Oncology Clinics of North America
Volume31
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • Chemoradiation
  • Locally advanced disease
  • Non–small cell lung cancer

ASJC Scopus subject areas

  • Hematology
  • Oncology

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