Treatment of liver metastases of carcinoid tumors

Håkan Ahlman, Gunnel Westberg, Bo Wängberg, Ola Nilsson, Ulf Tylen, Tore Scherstén, Lars Erik Tisell

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Liver metastases imply a major problem in patients with carcinoid tumors. Patients with localized disease should always undergo resection for cure. Patients with distant metastatic disease can also undergo resection for potential cure or symptom palliation because of the slow growth rate of many carcinoid tumors. In patients with the midgut carcinoid syndrome and bilobar hepatic disease we have performed primary surgery to relieve such symptoms as intestinal obstruction and ischemia, followed by successive embolizations of the hepatic arteries to reduce functional tumor burden in the liver. For optimal palliation, all patients with residual tumor were treated by octreotide. In a consecutive series of 64 patients with the midgut carcinoid syndrome we thus attained a 5-year survival rate of 70%. Fourteen of the patients underwent intentionally curative surgery (e.g., primary surgery followed by liver surgery). Of these patients, none died from their tumor disease during the period of study. The value of adjunctive interferon therapy is currently under evaluation.

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
JournalWorld Journal of Surgery
Volume20
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Carcinoid Tumor
Neoplasm Metastasis
Liver
Therapeutics
Octreotide
Intestinal Obstruction
Hepatic Artery
Residual Neoplasm
Tumor Burden
Interferons
Ischemia
Survival Rate
Growth

ASJC Scopus subject areas

  • Surgery

Cite this

Ahlman, H., Westberg, G., Wängberg, B., Nilsson, O., Tylen, U., Scherstén, T., & Tisell, L. E. (1996). Treatment of liver metastases of carcinoid tumors. World Journal of Surgery, 20(2), 196-202. https://doi.org/10.1007/s002689900030

Treatment of liver metastases of carcinoid tumors. / Ahlman, Håkan; Westberg, Gunnel; Wängberg, Bo; Nilsson, Ola; Tylen, Ulf; Scherstén, Tore; Tisell, Lars Erik.

In: World Journal of Surgery, Vol. 20, No. 2, 1996, p. 196-202.

Research output: Contribution to journalArticle

Ahlman, H, Westberg, G, Wängberg, B, Nilsson, O, Tylen, U, Scherstén, T & Tisell, LE 1996, 'Treatment of liver metastases of carcinoid tumors', World Journal of Surgery, vol. 20, no. 2, pp. 196-202. https://doi.org/10.1007/s002689900030
Ahlman H, Westberg G, Wängberg B, Nilsson O, Tylen U, Scherstén T et al. Treatment of liver metastases of carcinoid tumors. World Journal of Surgery. 1996;20(2):196-202. https://doi.org/10.1007/s002689900030
Ahlman, Håkan ; Westberg, Gunnel ; Wängberg, Bo ; Nilsson, Ola ; Tylen, Ulf ; Scherstén, Tore ; Tisell, Lars Erik. / Treatment of liver metastases of carcinoid tumors. In: World Journal of Surgery. 1996 ; Vol. 20, No. 2. pp. 196-202.
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