Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: A prospective, doubie-blind, randomized study

E. E. Pettersson, S. Rekola, Lars Berglund, K. G. Sundqvist, B. Angelin, U. Diczfalusy, I. Bjorkhem, J. Bergstrom

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

In several studies diets supplemented with fish oil containing a high proportion of omega-3-polyunsaturated fatty acids (w-3-PUFA) have been shown to produce beneficial effects, such as a reduction in blood pressure, lipid levels and inflammation, all of which may affect the course of IgA nephropathy. However, the results of hitherto published studies concerning IgA nephropathy have been inconclusive. We therefore carried out a prospective, randomized, placebo-controlled six-month study with a higher daily dose of w-3-PUFA than used in previous studies. Thirty-two adult patients with biopsy-proven IgA nephropathy and proteinuria completed the study: 15 were assigned to a fish-oil product with a high percentage of w-3-PUFA (K 85, with 55% eicosapentenoic and 30% docosahexenoic acid) and 17 to corn oil, 6g daily of either oil. At the start, no significant differences were found between the two groups (K85: 3 females/12 males, mean age 39 years (range 22-64), corn oil: 4 females/13 males, age 42 years (range 26-68). By six months, supplements of K85 resulted in a slight but significant reduction in glomerular filtration rate (GFR) compared to the start: 51Cr-EDTA: 63 ± 22 to 59 ± 21 ml/min/1.73 m2 (p<0.05), creatinine clearance: 91 ± 31 to 79 ± 25 ml/min (p<0.01), s-creatinine: 131 ± 39 to 139 ± 39 μmol/l, whereas no change in GFR was observed in the corn oil group. The urinary total protein and red blood cell excretions were not affected in any of the groups. At the start, most of the patients had mildly- to moderately elevated plasma total and LDL cholesterol (C) levels, about half of them having elevated levels of triglycerides (TG). K 85 supplements led to a significant (p<0.05) fall of TG (-18%), increase of LDL-C (+11%) and increase of ApoB (+8%). Corn oil supplements led to a significant (p<0.01) increase in HDL-C (+22%). We conclude from the results of this study that patients with IgA nephropathy with proteinuria and moderately reduced GFR do not benefit from treatment with high doses of w-3-PUFA regarding protein excretion and progression of renal failure.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalClinical Nephrology
Volume41
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

Corn Oil
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Immunoglobulin A
Glomerular Filtration Rate
Fish Oils
Proteinuria
Creatinine
Triglycerides
Fish Products
Docosahexaenoic Acids
Apolipoproteins B
Therapeutics
Edetic Acid
LDL Cholesterol
Renal Insufficiency
Oils
Proteins
Erythrocytes
Placebos

Keywords

  • Fish oil
  • Glomerular filtration rate
  • IgA nephropathy
  • Lipids

ASJC Scopus subject areas

  • Nephrology

Cite this

Pettersson, E. E., Rekola, S., Berglund, L., Sundqvist, K. G., Angelin, B., Diczfalusy, U., ... Bergstrom, J. (1994). Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: A prospective, doubie-blind, randomized study. Clinical Nephrology, 41(4), 183-190.

Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids : A prospective, doubie-blind, randomized study. / Pettersson, E. E.; Rekola, S.; Berglund, Lars; Sundqvist, K. G.; Angelin, B.; Diczfalusy, U.; Bjorkhem, I.; Bergstrom, J.

In: Clinical Nephrology, Vol. 41, No. 4, 1994, p. 183-190.

Research output: Contribution to journalArticle

Pettersson, EE, Rekola, S, Berglund, L, Sundqvist, KG, Angelin, B, Diczfalusy, U, Bjorkhem, I & Bergstrom, J 1994, 'Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: A prospective, doubie-blind, randomized study', Clinical Nephrology, vol. 41, no. 4, pp. 183-190.
Pettersson, E. E. ; Rekola, S. ; Berglund, Lars ; Sundqvist, K. G. ; Angelin, B. ; Diczfalusy, U. ; Bjorkhem, I. ; Bergstrom, J. / Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids : A prospective, doubie-blind, randomized study. In: Clinical Nephrology. 1994 ; Vol. 41, No. 4. pp. 183-190.
@article{afb85c7813cb41ff9f8506dbc86bb5df,
title = "Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: A prospective, doubie-blind, randomized study",
abstract = "In several studies diets supplemented with fish oil containing a high proportion of omega-3-polyunsaturated fatty acids (w-3-PUFA) have been shown to produce beneficial effects, such as a reduction in blood pressure, lipid levels and inflammation, all of which may affect the course of IgA nephropathy. However, the results of hitherto published studies concerning IgA nephropathy have been inconclusive. We therefore carried out a prospective, randomized, placebo-controlled six-month study with a higher daily dose of w-3-PUFA than used in previous studies. Thirty-two adult patients with biopsy-proven IgA nephropathy and proteinuria completed the study: 15 were assigned to a fish-oil product with a high percentage of w-3-PUFA (K 85, with 55{\%} eicosapentenoic and 30{\%} docosahexenoic acid) and 17 to corn oil, 6g daily of either oil. At the start, no significant differences were found between the two groups (K85: 3 females/12 males, mean age 39 years (range 22-64), corn oil: 4 females/13 males, age 42 years (range 26-68). By six months, supplements of K85 resulted in a slight but significant reduction in glomerular filtration rate (GFR) compared to the start: 51Cr-EDTA: 63 ± 22 to 59 ± 21 ml/min/1.73 m2 (p<0.05), creatinine clearance: 91 ± 31 to 79 ± 25 ml/min (p<0.01), s-creatinine: 131 ± 39 to 139 ± 39 μmol/l, whereas no change in GFR was observed in the corn oil group. The urinary total protein and red blood cell excretions were not affected in any of the groups. At the start, most of the patients had mildly- to moderately elevated plasma total and LDL cholesterol (C) levels, about half of them having elevated levels of triglycerides (TG). K 85 supplements led to a significant (p<0.05) fall of TG (-18{\%}), increase of LDL-C (+11{\%}) and increase of ApoB (+8{\%}). Corn oil supplements led to a significant (p<0.01) increase in HDL-C (+22{\%}). We conclude from the results of this study that patients with IgA nephropathy with proteinuria and moderately reduced GFR do not benefit from treatment with high doses of w-3-PUFA regarding protein excretion and progression of renal failure.",
keywords = "Fish oil, Glomerular filtration rate, IgA nephropathy, Lipids",
author = "Pettersson, {E. E.} and S. Rekola and Lars Berglund and Sundqvist, {K. G.} and B. Angelin and U. Diczfalusy and I. Bjorkhem and J. Bergstrom",
year = "1994",
language = "English (US)",
volume = "41",
pages = "183--190",
journal = "Clinical Nephrology",
issn = "0301-0430",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "4",

}

TY - JOUR

T1 - Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids

T2 - A prospective, doubie-blind, randomized study

AU - Pettersson, E. E.

AU - Rekola, S.

AU - Berglund, Lars

AU - Sundqvist, K. G.

AU - Angelin, B.

AU - Diczfalusy, U.

AU - Bjorkhem, I.

AU - Bergstrom, J.

PY - 1994

Y1 - 1994

N2 - In several studies diets supplemented with fish oil containing a high proportion of omega-3-polyunsaturated fatty acids (w-3-PUFA) have been shown to produce beneficial effects, such as a reduction in blood pressure, lipid levels and inflammation, all of which may affect the course of IgA nephropathy. However, the results of hitherto published studies concerning IgA nephropathy have been inconclusive. We therefore carried out a prospective, randomized, placebo-controlled six-month study with a higher daily dose of w-3-PUFA than used in previous studies. Thirty-two adult patients with biopsy-proven IgA nephropathy and proteinuria completed the study: 15 were assigned to a fish-oil product with a high percentage of w-3-PUFA (K 85, with 55% eicosapentenoic and 30% docosahexenoic acid) and 17 to corn oil, 6g daily of either oil. At the start, no significant differences were found between the two groups (K85: 3 females/12 males, mean age 39 years (range 22-64), corn oil: 4 females/13 males, age 42 years (range 26-68). By six months, supplements of K85 resulted in a slight but significant reduction in glomerular filtration rate (GFR) compared to the start: 51Cr-EDTA: 63 ± 22 to 59 ± 21 ml/min/1.73 m2 (p<0.05), creatinine clearance: 91 ± 31 to 79 ± 25 ml/min (p<0.01), s-creatinine: 131 ± 39 to 139 ± 39 μmol/l, whereas no change in GFR was observed in the corn oil group. The urinary total protein and red blood cell excretions were not affected in any of the groups. At the start, most of the patients had mildly- to moderately elevated plasma total and LDL cholesterol (C) levels, about half of them having elevated levels of triglycerides (TG). K 85 supplements led to a significant (p<0.05) fall of TG (-18%), increase of LDL-C (+11%) and increase of ApoB (+8%). Corn oil supplements led to a significant (p<0.01) increase in HDL-C (+22%). We conclude from the results of this study that patients with IgA nephropathy with proteinuria and moderately reduced GFR do not benefit from treatment with high doses of w-3-PUFA regarding protein excretion and progression of renal failure.

AB - In several studies diets supplemented with fish oil containing a high proportion of omega-3-polyunsaturated fatty acids (w-3-PUFA) have been shown to produce beneficial effects, such as a reduction in blood pressure, lipid levels and inflammation, all of which may affect the course of IgA nephropathy. However, the results of hitherto published studies concerning IgA nephropathy have been inconclusive. We therefore carried out a prospective, randomized, placebo-controlled six-month study with a higher daily dose of w-3-PUFA than used in previous studies. Thirty-two adult patients with biopsy-proven IgA nephropathy and proteinuria completed the study: 15 were assigned to a fish-oil product with a high percentage of w-3-PUFA (K 85, with 55% eicosapentenoic and 30% docosahexenoic acid) and 17 to corn oil, 6g daily of either oil. At the start, no significant differences were found between the two groups (K85: 3 females/12 males, mean age 39 years (range 22-64), corn oil: 4 females/13 males, age 42 years (range 26-68). By six months, supplements of K85 resulted in a slight but significant reduction in glomerular filtration rate (GFR) compared to the start: 51Cr-EDTA: 63 ± 22 to 59 ± 21 ml/min/1.73 m2 (p<0.05), creatinine clearance: 91 ± 31 to 79 ± 25 ml/min (p<0.01), s-creatinine: 131 ± 39 to 139 ± 39 μmol/l, whereas no change in GFR was observed in the corn oil group. The urinary total protein and red blood cell excretions were not affected in any of the groups. At the start, most of the patients had mildly- to moderately elevated plasma total and LDL cholesterol (C) levels, about half of them having elevated levels of triglycerides (TG). K 85 supplements led to a significant (p<0.05) fall of TG (-18%), increase of LDL-C (+11%) and increase of ApoB (+8%). Corn oil supplements led to a significant (p<0.01) increase in HDL-C (+22%). We conclude from the results of this study that patients with IgA nephropathy with proteinuria and moderately reduced GFR do not benefit from treatment with high doses of w-3-PUFA regarding protein excretion and progression of renal failure.

KW - Fish oil

KW - Glomerular filtration rate

KW - IgA nephropathy

KW - Lipids

UR - http://www.scopus.com/inward/record.url?scp=0028207268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028207268&partnerID=8YFLogxK

M3 - Article

C2 - 8026109

AN - SCOPUS:0028207268

VL - 41

SP - 183

EP - 190

JO - Clinical Nephrology

JF - Clinical Nephrology

SN - 0301-0430

IS - 4

ER -