Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012)

S. A. Collette, S. D. Allstadt, E. M. Chon, William Vernau, A. N. Smith, L. D. Garrett, K. Choy, Robert B Rebhun, C. O. Rodriguez, Katherine A Skorupski

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).

Original languageEnglish (US)
Pages (from-to)136-146
Number of pages11
JournalVeterinary and Comparative Oncology
Volume14
DOIs
StatePublished - Aug 1 2016

Fingerprint

Felidae
lymphoma
Non-Hodgkin's Lymphoma
Cats
cats
Maintenance
drug therapy
Vinca Alkaloids
Drug Therapy
Vinca
Therapeutics
Prednisolone
prednisolone
doxorubicin
cyclophosphamide
Doxorubicin
Cyclophosphamide
Disease-Free Survival
Lymphoma
Dogs

Keywords

  • cat
  • CHOP
  • feline
  • lymphoma
  • maintenance-free chemotherapy
  • survival

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol : 119 cases (2004-2012). / Collette, S. A.; Allstadt, S. D.; Chon, E. M.; Vernau, William; Smith, A. N.; Garrett, L. D.; Choy, K.; Rebhun, Robert B; Rodriguez, C. O.; Skorupski, Katherine A.

In: Veterinary and Comparative Oncology, Vol. 14, 01.08.2016, p. 136-146.

Research output: Contribution to journalArticle

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abstract = "CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).",
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AU - Chon, E. M.

AU - Vernau, William

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