TY - JOUR
T1 - Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion
AU - Gupta, Mrinali Patel
AU - Coombs, Peter
AU - Prockop, Susan E.
AU - Hasan, Aisha A.
AU - Doubrovina, Ekatarina
AU - O'Reilly, Richard J.
AU - Cohen, Stuart H
AU - Park, Susanna Soon Chun
AU - Kiss, Szilárd
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.
AB - Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.
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U2 - 10.3928/23258160-20150101-14
DO - 10.3928/23258160-20150101-14
M3 - Article
C2 - 25559515
AN - SCOPUS:84920725098
VL - 46
SP - 80
EP - 82
JO - Ophthalmic Surgery
JF - Ophthalmic Surgery
SN - 2325-8160
IS - 1
ER -