Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

Mrinali Patel Gupta, Peter Coombs, Susan E. Prockop, Aisha A. Hasan, Ekatarina Doubrovina, Richard J. O'Reilly, Stuart H Cohen, Susanna Soon Chun Park, Szilárd Kiss

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

Original languageEnglish (US)
Pages (from-to)80-82
Number of pages3
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

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