Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

Mrinali Patel Gupta; Peter Coombs; Susan E. Prockop; Aisha A. Hasan; Ekatarina Doubrovina; Richard J. O'Reilly; Stuart H Cohen; Susanna Soon Chun Park; Szilárd Kiss

doi:10.3928/23258160-20150101-14

Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

Mrinali Patel Gupta, Peter Coombs, Susan E. Prockop, Aisha A. Hasan, Ekatarina Doubrovina, Richard J. O'Reilly, Stuart H Cohen, Susanna Soon Chun Park, Szilárd Kiss

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

Original language	English (US)
Pages (from-to)	80-82
Number of pages	3
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	46
Issue number	1
DOIs	https://doi.org/10.3928/23258160-20150101-14
State	Published - Jan 1 2015

ASJC Scopus subject areas

Ophthalmology
Surgery

Access to Document

10.3928/23258160-20150101-14

Fingerprint Dive into the research topics of 'Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion'. Together they form a unique fingerprint.

Cite this

Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion. / Gupta, Mrinali Patel; Coombs, Peter; Prockop, Susan E.; Hasan, Aisha A.; Doubrovina, Ekatarina; O'Reilly, Richard J.; Cohen, Stuart H ; Park, Susanna Soon Chun; Kiss, Szilárd.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 1, 01.01.2015, p. 80-82.

Research output: Contribution to journal › Article › peer-review

@article{67209cc3daa045a98f2b7635aed03806,

title = "Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion",

abstract = "Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.",

author = "Gupta, {Mrinali Patel} and Peter Coombs and Prockop, {Susan E.} and Hasan, {Aisha A.} and Ekatarina Doubrovina and O'Reilly, {Richard J.} and Cohen, {Stuart H} and Park, {Susanna Soon Chun} and Szil{\'a}rd Kiss",

year = "2015",

month = jan,

day = "1",

doi = "10.3928/23258160-20150101-14",

language = "English (US)",

volume = "46",

pages = "80--82",

journal = "Ophthalmic Surgery Lasers and Imaging Retina",

issn = "2325-8160",

publisher = "Slack Incorporated",

number = "1",

}

TY - JOUR

T1 - Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

AU - Gupta, Mrinali Patel

AU - Coombs, Peter

AU - Prockop, Susan E.

AU - Hasan, Aisha A.

AU - Doubrovina, Ekatarina

AU - O'Reilly, Richard J.

AU - Cohen, Stuart H

AU - Park, Susanna Soon Chun

AU - Kiss, Szilárd

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

AB - Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

UR - http://www.scopus.com/inward/record.url?scp=84920725098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920725098&partnerID=8YFLogxK

U2 - 10.3928/23258160-20150101-14

DO - 10.3928/23258160-20150101-14

M3 - Article

C2 - 25559515

AN - SCOPUS:84920725098

VL - 46

SP - 80

EP - 82

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

SN - 2325-8160

IS - 1

ER -