Abstract
Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 80-82 |
| Number of pages | 3 |
| Journal | Ophthalmic Surgery Lasers and Imaging Retina |
| Volume | 46 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
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ASJC Scopus subject areas
- Ophthalmology
- Surgery
Cite this
Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion. / Gupta, Mrinali Patel; Coombs, Peter; Prockop, Susan E.; Hasan, Aisha A.; Doubrovina, Ekatarina; O'Reilly, Richard J.; Cohen, Stuart H; Park, Susanna Soon Chun; Kiss, Szilárd.
In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 1, 01.01.2015, p. 80-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion
AU - Gupta, Mrinali Patel
AU - Coombs, Peter
AU - Prockop, Susan E.
AU - Hasan, Aisha A.
AU - Doubrovina, Ekatarina
AU - O'Reilly, Richard J.
AU - Cohen, Stuart H
AU - Park, Susanna Soon Chun
AU - Kiss, Szilárd
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.
AB - Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.
UR - http://www.scopus.com/inward/record.url?scp=84920725098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920725098&partnerID=8YFLogxK
U2 - 10.3928/23258160-20150101-14
DO - 10.3928/23258160-20150101-14
M3 - Article
C2 - 25559515
AN - SCOPUS:84920725098
VL - 46
SP - 80
EP - 82
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 1
ER -