Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

Mrinali Patel Gupta; Peter Coombs; Susan E. Prockop; Aisha A. Hasan; Ekatarina Doubrovina; Richard J. O'Reilly; Stuart H Cohen; Susanna Soon Chun Park; Szilárd Kiss

doi:10.3928/23258160-20150101-14

Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

Mrinali Patel Gupta, Peter Coombs, Susan E. Prockop, Aisha A. Hasan, Ekatarina Doubrovina, Richard J. O'Reilly, Stuart H Cohen, Susanna Soon Chun Park, Szilárd Kiss

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

Original language	English (US)
Pages (from-to)	80-82
Number of pages	3
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	46
Issue number	1
DOIs	https://doi.org/10.3928/23258160-20150101-14
State	Published - Jan 1 2015

ASJC Scopus subject areas

Ophthalmology
Surgery

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Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion. / Gupta, Mrinali Patel; Coombs, Peter; Prockop, Susan E.; Hasan, Aisha A.; Doubrovina, Ekatarina; O'Reilly, Richard J.; Cohen, Stuart H ; Park, Susanna Soon Chun; Kiss, Szilárd.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 1, 01.01.2015, p. 80-82.

Research output: Contribution to journal › Article › peer-review

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abstract = "Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.",

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AU - Hasan, Aisha A.

AU - Doubrovina, Ekatarina

AU - O'Reilly, Richard J.

AU - Cohen, Stuart H

AU - Park, Susanna Soon Chun

AU - Kiss, Szilárd

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AB - Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

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Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

Abstract

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