Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion

Mrinali Patel Gupta, Peter Coombs, Susan E. Prockop, Aisha A. Hasan, Ekatarina Doubrovina, Richard J. O'Reilly, Stuart H Cohen, Susanna Soon Chun Park, Szilárd Kiss

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

Original languageEnglish (US)
Pages (from-to)80-82
Number of pages3
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Cytomegalovirus Retinitis
Cytomegalovirus
T-Lymphocytes
Leukocytes
Retinitis
Viremia
Cytomegalovirus Infections
Immunocompromised Host
Therapeutics
Antiviral Agents
Tissue Donors
Infection

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Gupta, M. P., Coombs, P., Prockop, S. E., Hasan, A. A., Doubrovina, E., O'Reilly, R. J., ... Kiss, S. (2015). Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion. Ophthalmic Surgery Lasers and Imaging Retina, 46(1), 80-82. https://doi.org/10.3928/23258160-20150101-14

Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion. / Gupta, Mrinali Patel; Coombs, Peter; Prockop, Susan E.; Hasan, Aisha A.; Doubrovina, Ekatarina; O'Reilly, Richard J.; Cohen, Stuart H; Park, Susanna Soon Chun; Kiss, Szilárd.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 1, 01.01.2015, p. 80-82.

Research output: Contribution to journalArticle

Gupta, Mrinali Patel ; Coombs, Peter ; Prockop, Susan E. ; Hasan, Aisha A. ; Doubrovina, Ekatarina ; O'Reilly, Richard J. ; Cohen, Stuart H ; Park, Susanna Soon Chun ; Kiss, Szilárd. / Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion. In: Ophthalmic Surgery Lasers and Imaging Retina. 2015 ; Vol. 46, No. 1. pp. 80-82.
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