Treatment of Cutaneous Melanoma

Mary Ann N Johnson; April W. Armstrong

doi:10.1002/9781118357606.ch31

Treatment of Cutaneous Melanoma

Mary Ann N Johnson, April W. Armstrong

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter briefly discusses the primary cutaneous melanoma and its incidence, risk factors, diagnosis, prognosis and treatment objectives. It also describes the recommendations for surgical excision margins based on the Breslow thickness of the melanoma. The management of patients with lentigo maligna (LM) or lentigo maligna melanoma (LMM), and the role of sentinel lymph-node biopsy are discussed in detail. The chapter also discusses the therapies to improve overall survival in patients with metastatic malignant melanoma. It also discusses the question: Does antisense therapy against B-cell lymphoma 2 improve outcomes in patients with metastatic melanoma. Developments in the systemic treatment of melanoma have resulted in improved survival for advance metastatic melanoma (Stage IV). The role of cytotoxic chemotherapeutic agents, as monotherapy and in combination regimens, is limited in initial treatment for metastatic melanoma.

Original language	English (US)
Title of host publication	Evidence-Based Dermatology: Third Edition
Publisher	Wiley Blackwell
Pages	231-240
Number of pages	10
ISBN (Print)	9781118357606, 9781118357675
DOIs	https://doi.org/10.1002/9781118357606.ch31
State	Published - Aug 11 2014
Externally published	Yes

Keywords

Antisense therapy
Cytotoxic chemotherapeutic agents
Lentigo maligna melanoma (LMM)
Metastatic malignant melanoma
Primary cutaneous melanoma
Sentinel lymph-node biopsy

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1002/9781118357606.ch31

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abstract = "This chapter briefly discusses the primary cutaneous melanoma and its incidence, risk factors, diagnosis, prognosis and treatment objectives. It also describes the recommendations for surgical excision margins based on the Breslow thickness of the melanoma. The management of patients with lentigo maligna (LM) or lentigo maligna melanoma (LMM), and the role of sentinel lymph-node biopsy are discussed in detail. The chapter also discusses the therapies to improve overall survival in patients with metastatic malignant melanoma. It also discusses the question: Does antisense therapy against B-cell lymphoma 2 improve outcomes in patients with metastatic melanoma. Developments in the systemic treatment of melanoma have resulted in improved survival for advance metastatic melanoma (Stage IV). The role of cytotoxic chemotherapeutic agents, as monotherapy and in combination regimens, is limited in initial treatment for metastatic melanoma.",

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