Treatment of canine osseous tumors with photodynamic therapy: A pilot study

S. Burch, C. London, B. Seguin, C. Rodriguez, B. C. Wilson, S. K. Bisland

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Photodynamic therapy uses nonthermal coherent light delivered via fiber optic cable to locally activate a photosensitive chemotherapeutic agent that ablates tumor tissue. Owing to the limitations of light penetration, it is unknown whether photodynamic therapy can treat large osseous tumors. We determined whether photodynamic therapy can induce necrosis in large osseous tumors, and if so, to quantify the volume of treated tissue. In a pilot study we treated seven dogs with spontaneous osteosarcomas of the distal radius. Tumors were imaged with MRI before and 48 hours after treatment, and the volumes of hypointense regions were compared. The treated limbs were amputated immediately after imaging at 48 hours and sectioned corresponding to the MR axial images. We identified tumor necrosis histologically; the regions of necrosis corresponded anatomically to hypointense tissue on MRI. The mean volume of necrotic tissue seen on MRI after photodynamic therapy was 21,305 mm3 compared with a pretreatment volume of 6108 mm3. These pilot data suggest photodynamic therapy penetrates relatively large canine osseous tumors and may be a useful adjunct for treatment of bone tumors.

Original languageEnglish (US)
Pages (from-to)1028-1034
Number of pages7
JournalClinical Orthopaedics and Related Research
Volume467
Issue number4
DOIs
StatePublished - Apr 2009

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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    Burch, S., London, C., Seguin, B., Rodriguez, C., Wilson, B. C., & Bisland, S. K. (2009). Treatment of canine osseous tumors with photodynamic therapy: A pilot study. Clinical Orthopaedics and Related Research, 467(4), 1028-1034. https://doi.org/10.1007/s11999-008-0678-5