Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate

Randy C. Lynn, Edward C Feldman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The efficacy of a microcrystalline desoxycorticosterone pivalate (DOCP) injection in the management of canine hypoadrenocorticism (CHAC) was investigated in 21 dogs. On day 0 dogs previously diagnosed with CHAC were given a physical examination and an injection (2.2 mg/kg) of DOCP. This was repeated on days 25 and 50. On day 75 of the study a final physical examination was performed and the success of therapy was evaluated. Blood samples were obtained for serum chemical analysis (Na+, K+, Cl-, BUN & creatinine) on day 0 and day 75. Body weight increased steadily from a mean (±sd) of 25.5 ± 14.2 kg on day 0 to 27.1 ± 14.8 kg on day 75. The mean serum biochemistry values on day 0 were outside normal limits for Na+ (139.3 ± 9.2 mEq/l), K+ (5.4 ± 0.9 mEq/l), and Na+ K+ ratio [ (26.4 ± 4.8) 1]. On day 75, after three injections of DOCP, the values for Na+ (148.2 ± 5.2 mEq/l), K+ (4.9 ± 0.6 mEq/l), and Na+ K+ [ (30.8 ± 4.2) 1] were normal and significantly (P < 0.01) different from the values on day 0. All dogs in the study did well on DOCP therapy. The few side effects observed resolved with concomitant administration of prednisolone and/or adjustment of the DOCP dose. All clients elected to continue DOCP therapy after the trial ended, and the dogs continue to do well.

Original languageEnglish (US)
Pages (from-to)478-483
Number of pages6
JournalBritish Veterinary Journal
Volume147
Issue number5
DOIs
StatePublished - 1991

Fingerprint

desoxycorticosterone
hypoadrenocorticism
Canidae
dogs
Dogs
injection
blood serum
clinical examination
therapeutics
Injections
Physical Examination
Therapeutics
prednisolone
Blood Urea Nitrogen
Prednisolone
Serum
chemical analysis
Biochemistry
biochemistry
creatinine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate. / Lynn, Randy C.; Feldman, Edward C.

In: British Veterinary Journal, Vol. 147, No. 5, 1991, p. 478-483.

Research output: Contribution to journalArticle

@article{1537eb4138c1429aa88a48400ded0a84,
title = "Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate",
abstract = "The efficacy of a microcrystalline desoxycorticosterone pivalate (DOCP) injection in the management of canine hypoadrenocorticism (CHAC) was investigated in 21 dogs. On day 0 dogs previously diagnosed with CHAC were given a physical examination and an injection (2.2 mg/kg) of DOCP. This was repeated on days 25 and 50. On day 75 of the study a final physical examination was performed and the success of therapy was evaluated. Blood samples were obtained for serum chemical analysis (Na+, K+, Cl-, BUN & creatinine) on day 0 and day 75. Body weight increased steadily from a mean (±sd) of 25.5 ± 14.2 kg on day 0 to 27.1 ± 14.8 kg on day 75. The mean serum biochemistry values on day 0 were outside normal limits for Na+ (139.3 ± 9.2 mEq/l), K+ (5.4 ± 0.9 mEq/l), and Na+ K+ ratio [ (26.4 ± 4.8) 1]. On day 75, after three injections of DOCP, the values for Na+ (148.2 ± 5.2 mEq/l), K+ (4.9 ± 0.6 mEq/l), and Na+ K+ [ (30.8 ± 4.2) 1] were normal and significantly (P < 0.01) different from the values on day 0. All dogs in the study did well on DOCP therapy. The few side effects observed resolved with concomitant administration of prednisolone and/or adjustment of the DOCP dose. All clients elected to continue DOCP therapy after the trial ended, and the dogs continue to do well.",
author = "Lynn, {Randy C.} and Feldman, {Edward C}",
year = "1991",
doi = "10.1016/0007-1935(91)90091-Z",
language = "English (US)",
volume = "147",
pages = "478--483",
journal = "Veterinary Journal",
issn = "1090-0233",
publisher = "Bailliere Tindall Ltd",
number = "5",

}

TY - JOUR

T1 - Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate

AU - Lynn, Randy C.

AU - Feldman, Edward C

PY - 1991

Y1 - 1991

N2 - The efficacy of a microcrystalline desoxycorticosterone pivalate (DOCP) injection in the management of canine hypoadrenocorticism (CHAC) was investigated in 21 dogs. On day 0 dogs previously diagnosed with CHAC were given a physical examination and an injection (2.2 mg/kg) of DOCP. This was repeated on days 25 and 50. On day 75 of the study a final physical examination was performed and the success of therapy was evaluated. Blood samples were obtained for serum chemical analysis (Na+, K+, Cl-, BUN & creatinine) on day 0 and day 75. Body weight increased steadily from a mean (±sd) of 25.5 ± 14.2 kg on day 0 to 27.1 ± 14.8 kg on day 75. The mean serum biochemistry values on day 0 were outside normal limits for Na+ (139.3 ± 9.2 mEq/l), K+ (5.4 ± 0.9 mEq/l), and Na+ K+ ratio [ (26.4 ± 4.8) 1]. On day 75, after three injections of DOCP, the values for Na+ (148.2 ± 5.2 mEq/l), K+ (4.9 ± 0.6 mEq/l), and Na+ K+ [ (30.8 ± 4.2) 1] were normal and significantly (P < 0.01) different from the values on day 0. All dogs in the study did well on DOCP therapy. The few side effects observed resolved with concomitant administration of prednisolone and/or adjustment of the DOCP dose. All clients elected to continue DOCP therapy after the trial ended, and the dogs continue to do well.

AB - The efficacy of a microcrystalline desoxycorticosterone pivalate (DOCP) injection in the management of canine hypoadrenocorticism (CHAC) was investigated in 21 dogs. On day 0 dogs previously diagnosed with CHAC were given a physical examination and an injection (2.2 mg/kg) of DOCP. This was repeated on days 25 and 50. On day 75 of the study a final physical examination was performed and the success of therapy was evaluated. Blood samples were obtained for serum chemical analysis (Na+, K+, Cl-, BUN & creatinine) on day 0 and day 75. Body weight increased steadily from a mean (±sd) of 25.5 ± 14.2 kg on day 0 to 27.1 ± 14.8 kg on day 75. The mean serum biochemistry values on day 0 were outside normal limits for Na+ (139.3 ± 9.2 mEq/l), K+ (5.4 ± 0.9 mEq/l), and Na+ K+ ratio [ (26.4 ± 4.8) 1]. On day 75, after three injections of DOCP, the values for Na+ (148.2 ± 5.2 mEq/l), K+ (4.9 ± 0.6 mEq/l), and Na+ K+ [ (30.8 ± 4.2) 1] were normal and significantly (P < 0.01) different from the values on day 0. All dogs in the study did well on DOCP therapy. The few side effects observed resolved with concomitant administration of prednisolone and/or adjustment of the DOCP dose. All clients elected to continue DOCP therapy after the trial ended, and the dogs continue to do well.

UR - http://www.scopus.com/inward/record.url?scp=0025776364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025776364&partnerID=8YFLogxK

U2 - 10.1016/0007-1935(91)90091-Z

DO - 10.1016/0007-1935(91)90091-Z

M3 - Article

VL - 147

SP - 478

EP - 483

JO - Veterinary Journal

JF - Veterinary Journal

SN - 1090-0233

IS - 5

ER -