Abstract
The efficacy of a microcrystalline desoxycorticosterone pivalate (DOCP) injection in the management of canine hypoadrenocorticism (CHAC) was investigated in 21 dogs. On day 0 dogs previously diagnosed with CHAC were given a physical examination and an injection (2.2 mg/kg) of DOCP. This was repeated on days 25 and 50. On day 75 of the study a final physical examination was performed and the success of therapy was evaluated. Blood samples were obtained for serum chemical analysis (Na+, K+, Cl-, BUN & creatinine) on day 0 and day 75. Body weight increased steadily from a mean (±sd) of 25.5 ± 14.2 kg on day 0 to 27.1 ± 14.8 kg on day 75. The mean serum biochemistry values on day 0 were outside normal limits for Na+ (139.3 ± 9.2 mEq/l), K+ (5.4 ± 0.9 mEq/l), and Na+ K+ ratio [ (26.4 ± 4.8) 1]. On day 75, after three injections of DOCP, the values for Na+ (148.2 ± 5.2 mEq/l), K+ (4.9 ± 0.6 mEq/l), and Na+ K+ [ (30.8 ± 4.2) 1] were normal and significantly (P < 0.01) different from the values on day 0. All dogs in the study did well on DOCP therapy. The few side effects observed resolved with concomitant administration of prednisolone and/or adjustment of the DOCP dose. All clients elected to continue DOCP therapy after the trial ended, and the dogs continue to do well.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 478-483 |
| Number of pages | 6 |
| Journal | British Veterinary Journal |
| Volume | 147 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1991 |
Fingerprint
ASJC Scopus subject areas
- veterinary(all)
Cite this
Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate. / Lynn, Randy C.; Feldman, Edward C.
In: British Veterinary Journal, Vol. 147, No. 5, 1991, p. 478-483.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate
AU - Lynn, Randy C.
AU - Feldman, Edward C
PY - 1991
Y1 - 1991
N2 - The efficacy of a microcrystalline desoxycorticosterone pivalate (DOCP) injection in the management of canine hypoadrenocorticism (CHAC) was investigated in 21 dogs. On day 0 dogs previously diagnosed with CHAC were given a physical examination and an injection (2.2 mg/kg) of DOCP. This was repeated on days 25 and 50. On day 75 of the study a final physical examination was performed and the success of therapy was evaluated. Blood samples were obtained for serum chemical analysis (Na+, K+, Cl-, BUN & creatinine) on day 0 and day 75. Body weight increased steadily from a mean (±sd) of 25.5 ± 14.2 kg on day 0 to 27.1 ± 14.8 kg on day 75. The mean serum biochemistry values on day 0 were outside normal limits for Na+ (139.3 ± 9.2 mEq/l), K+ (5.4 ± 0.9 mEq/l), and Na+ K+ ratio [ (26.4 ± 4.8) 1]. On day 75, after three injections of DOCP, the values for Na+ (148.2 ± 5.2 mEq/l), K+ (4.9 ± 0.6 mEq/l), and Na+ K+ [ (30.8 ± 4.2) 1] were normal and significantly (P < 0.01) different from the values on day 0. All dogs in the study did well on DOCP therapy. The few side effects observed resolved with concomitant administration of prednisolone and/or adjustment of the DOCP dose. All clients elected to continue DOCP therapy after the trial ended, and the dogs continue to do well.
AB - The efficacy of a microcrystalline desoxycorticosterone pivalate (DOCP) injection in the management of canine hypoadrenocorticism (CHAC) was investigated in 21 dogs. On day 0 dogs previously diagnosed with CHAC were given a physical examination and an injection (2.2 mg/kg) of DOCP. This was repeated on days 25 and 50. On day 75 of the study a final physical examination was performed and the success of therapy was evaluated. Blood samples were obtained for serum chemical analysis (Na+, K+, Cl-, BUN & creatinine) on day 0 and day 75. Body weight increased steadily from a mean (±sd) of 25.5 ± 14.2 kg on day 0 to 27.1 ± 14.8 kg on day 75. The mean serum biochemistry values on day 0 were outside normal limits for Na+ (139.3 ± 9.2 mEq/l), K+ (5.4 ± 0.9 mEq/l), and Na+ K+ ratio [ (26.4 ± 4.8) 1]. On day 75, after three injections of DOCP, the values for Na+ (148.2 ± 5.2 mEq/l), K+ (4.9 ± 0.6 mEq/l), and Na+ K+ [ (30.8 ± 4.2) 1] were normal and significantly (P < 0.01) different from the values on day 0. All dogs in the study did well on DOCP therapy. The few side effects observed resolved with concomitant administration of prednisolone and/or adjustment of the DOCP dose. All clients elected to continue DOCP therapy after the trial ended, and the dogs continue to do well.
UR - http://www.scopus.com/inward/record.url?scp=0025776364&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025776364&partnerID=8YFLogxK
U2 - 10.1016/0007-1935(91)90091-Z
DO - 10.1016/0007-1935(91)90091-Z
M3 - Article
VL - 147
SP - 478
EP - 483
JO - Veterinary Journal
JF - Veterinary Journal
SN - 1090-0233
IS - 5
ER -