TY - JOUR
T1 - Treatment of γ-aminobutyric acidB receptor-antibody autoimmune encephalitis with oral corticosteroids
AU - Goldenholz, Daniel M.
AU - Wong, Victoria S S
AU - Bateman, Lisa M.
AU - Apperson, Michelle L
AU - Oskarsson, Bjorn E
AU - Akhtar, Shahrzad
AU - Wheelock, Vicki L
PY - 2012/8
Y1 - 2012/8
N2 - Background : Autoimmune encephalitis is increasingly identified as a cause of nonviral, idiopathic encephalitis. Present treatment algorithms recommend costly immune-modulating treatments and do not identify a role for oral corticosteroids. Objective: To present a patient with γ-aminobutyric acidB receptor-antibody encephalitis before and after treatment with oral corticosteroids. Design : Case report. Setting: The inpatient course as well as outpatient fol-low- up is discussed. Patient: A 43-year-old man with initial presentation of seizures and altered mental status. Intervention : Our patient was treated with an extended course of oral corticosteroids as an outpatient. Results: After treatment with oral corticosteroids, our patient had steady clinical improvement, achieved seizure freedom, and experienced improved mental status to within normal limits. Conclusions: This case supports the use of low-cost oral corticosteroids in treating patients with γ-aminobutyric acidB receptor-antibody encephalitis.
AB - Background : Autoimmune encephalitis is increasingly identified as a cause of nonviral, idiopathic encephalitis. Present treatment algorithms recommend costly immune-modulating treatments and do not identify a role for oral corticosteroids. Objective: To present a patient with γ-aminobutyric acidB receptor-antibody encephalitis before and after treatment with oral corticosteroids. Design : Case report. Setting: The inpatient course as well as outpatient fol-low- up is discussed. Patient: A 43-year-old man with initial presentation of seizures and altered mental status. Intervention : Our patient was treated with an extended course of oral corticosteroids as an outpatient. Results: After treatment with oral corticosteroids, our patient had steady clinical improvement, achieved seizure freedom, and experienced improved mental status to within normal limits. Conclusions: This case supports the use of low-cost oral corticosteroids in treating patients with γ-aminobutyric acidB receptor-antibody encephalitis.
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U2 - 10.1001/archneurol.2012.197
DO - 10.1001/archneurol.2012.197
M3 - Article
C2 - 22507884
AN - SCOPUS:84865623557
VL - 69
SP - 1061
EP - 1063
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 8
ER -