Traveling waves in actin dynamics and cell motility.

Jun Allard, Alex Mogilner

Research output: Contribution to journalArticle

Abstract

Much of current understanding of cell motility arose from studying steady treadmilling of actin arrays. Recently, there have been a growing number of observations of a more complex, non-steady, actin behavior, including self-organized waves. It is becoming clear that these waves result from activation and inhibition feedbacks in actin dynamics acting on different scales, but the exact molecular nature of these feedbacks and the respective roles of biomechanics and biochemistry are still unclear. Here, we review recent advances achieved in experimental and theoretical studies of actin waves and discuss mechanisms and physiological significance of wavy protrusions.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume25
Issue number1
StatePublished - Feb 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

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