Transmural Ileal Ganglioneuromatosis in a Young Boer Goat (Capra hircus)

M. F. Sheley, Robert Higgins, Asli Mete

Research output: Contribution to journalArticle

Abstract

A diagnosis of transmural ileal ganglioneuromatosis was made in a 15-day-old goat that was found dead following a period of diarrhoea and inappetence. Grossly, the entire length of the wall of the ileum was pale and firm with a variably segmental to transmural thickening. Microscopically, the ileal transmural thickening was due to a diffuse proliferation of both ganglionic and glial cells forming cell nests or packets that infiltrated the wall and into the mesentery surrounding a mesenteric lymph node. The neoplastic ganglionic cells wereimmunoreactive for S100, synaptophysin and triple neurofilament, while the glial spindle cells were immunoreactive with glial fibrillary acidic protein, S100 and laminin confirming their Schwann cell identity. Nerve fibres expressing neurofilament protein 200 and phosphorylated neurofilament (SMI-31) were observed rarely. Ganglioneuromatosis is defined as diffuse exuberant proliferation of all components of the intestinal ganglionic plexuses. In man, the transmural form has more grave clinical consequences than a focal pattern and is commonly associated with germline mutations in the RET proto-oncogene. Whether there is any comparable molecular genetic abnormality in animals remains unknown; however, ganglioneuromatosis needs to be included in the differential diagnosis of tumours of the autonomic enteric nervous system.

Original languageEnglish (US)
Pages (from-to)190-194
Number of pages5
JournalJournal of Comparative Pathology
Volume151
Issue number2-3
DOIs
StatePublished - 2014

Fingerprint

Boer (goat breed)
Intermediate Filaments
neuroglia
Goats
Neuroglia
goats
Enteric Nervous System
Neurofilament Proteins
Synaptophysin
Mesentery
Proto-Oncogenes
Germ-Line Mutation
Schwann Cells
Glial Fibrillary Acidic Protein
Autonomic Nervous System
Laminin
Ileum
Nerve Fibers
proto-oncogenes
Molecular Biology

Keywords

  • Ganglioneuromatosis
  • Goat
  • Immunohistochemistry
  • Small intestine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Transmural Ileal Ganglioneuromatosis in a Young Boer Goat (Capra hircus). / Sheley, M. F.; Higgins, Robert; Mete, Asli.

In: Journal of Comparative Pathology, Vol. 151, No. 2-3, 2014, p. 190-194.

Research output: Contribution to journalArticle

@article{104ae83b5add49e18f2e567283fe779a,
title = "Transmural Ileal Ganglioneuromatosis in a Young Boer Goat (Capra hircus)",
abstract = "A diagnosis of transmural ileal ganglioneuromatosis was made in a 15-day-old goat that was found dead following a period of diarrhoea and inappetence. Grossly, the entire length of the wall of the ileum was pale and firm with a variably segmental to transmural thickening. Microscopically, the ileal transmural thickening was due to a diffuse proliferation of both ganglionic and glial cells forming cell nests or packets that infiltrated the wall and into the mesentery surrounding a mesenteric lymph node. The neoplastic ganglionic cells wereimmunoreactive for S100, synaptophysin and triple neurofilament, while the glial spindle cells were immunoreactive with glial fibrillary acidic protein, S100 and laminin confirming their Schwann cell identity. Nerve fibres expressing neurofilament protein 200 and phosphorylated neurofilament (SMI-31) were observed rarely. Ganglioneuromatosis is defined as diffuse exuberant proliferation of all components of the intestinal ganglionic plexuses. In man, the transmural form has more grave clinical consequences than a focal pattern and is commonly associated with germline mutations in the RET proto-oncogene. Whether there is any comparable molecular genetic abnormality in animals remains unknown; however, ganglioneuromatosis needs to be included in the differential diagnosis of tumours of the autonomic enteric nervous system.",
keywords = "Ganglioneuromatosis, Goat, Immunohistochemistry, Small intestine",
author = "Sheley, {M. F.} and Robert Higgins and Asli Mete",
year = "2014",
doi = "10.1016/j.jcpa.2014.04.012",
language = "English (US)",
volume = "151",
pages = "190--194",
journal = "Journal of Comparative Pathology",
issn = "0021-9975",
publisher = "W.B. Saunders Ltd",
number = "2-3",

}

TY - JOUR

T1 - Transmural Ileal Ganglioneuromatosis in a Young Boer Goat (Capra hircus)

AU - Sheley, M. F.

AU - Higgins, Robert

AU - Mete, Asli

PY - 2014

Y1 - 2014

N2 - A diagnosis of transmural ileal ganglioneuromatosis was made in a 15-day-old goat that was found dead following a period of diarrhoea and inappetence. Grossly, the entire length of the wall of the ileum was pale and firm with a variably segmental to transmural thickening. Microscopically, the ileal transmural thickening was due to a diffuse proliferation of both ganglionic and glial cells forming cell nests or packets that infiltrated the wall and into the mesentery surrounding a mesenteric lymph node. The neoplastic ganglionic cells wereimmunoreactive for S100, synaptophysin and triple neurofilament, while the glial spindle cells were immunoreactive with glial fibrillary acidic protein, S100 and laminin confirming their Schwann cell identity. Nerve fibres expressing neurofilament protein 200 and phosphorylated neurofilament (SMI-31) were observed rarely. Ganglioneuromatosis is defined as diffuse exuberant proliferation of all components of the intestinal ganglionic plexuses. In man, the transmural form has more grave clinical consequences than a focal pattern and is commonly associated with germline mutations in the RET proto-oncogene. Whether there is any comparable molecular genetic abnormality in animals remains unknown; however, ganglioneuromatosis needs to be included in the differential diagnosis of tumours of the autonomic enteric nervous system.

AB - A diagnosis of transmural ileal ganglioneuromatosis was made in a 15-day-old goat that was found dead following a period of diarrhoea and inappetence. Grossly, the entire length of the wall of the ileum was pale and firm with a variably segmental to transmural thickening. Microscopically, the ileal transmural thickening was due to a diffuse proliferation of both ganglionic and glial cells forming cell nests or packets that infiltrated the wall and into the mesentery surrounding a mesenteric lymph node. The neoplastic ganglionic cells wereimmunoreactive for S100, synaptophysin and triple neurofilament, while the glial spindle cells were immunoreactive with glial fibrillary acidic protein, S100 and laminin confirming their Schwann cell identity. Nerve fibres expressing neurofilament protein 200 and phosphorylated neurofilament (SMI-31) were observed rarely. Ganglioneuromatosis is defined as diffuse exuberant proliferation of all components of the intestinal ganglionic plexuses. In man, the transmural form has more grave clinical consequences than a focal pattern and is commonly associated with germline mutations in the RET proto-oncogene. Whether there is any comparable molecular genetic abnormality in animals remains unknown; however, ganglioneuromatosis needs to be included in the differential diagnosis of tumours of the autonomic enteric nervous system.

KW - Ganglioneuromatosis

KW - Goat

KW - Immunohistochemistry

KW - Small intestine

UR - http://www.scopus.com/inward/record.url?scp=84905900690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905900690&partnerID=8YFLogxK

U2 - 10.1016/j.jcpa.2014.04.012

DO - 10.1016/j.jcpa.2014.04.012

M3 - Article

C2 - 24975898

AN - SCOPUS:84905900690

VL - 151

SP - 190

EP - 194

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

SN - 0021-9975

IS - 2-3

ER -