Transmitted Ultrasound Pressure Variation in Micro Blood Vessel Phantoms

Shengping Qin, Dustin E. Kruse, Katherine W. Ferrara

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Silica, cellulose and polymethylmethacrylate tubes with inner diameters of ten to a few hundred microns are commonly used as blood vessel phantoms in in vitro studies of microbubble or nanodroplet behavior during insonation. However, a detailed investigation of the ultrasonic fields within these micro-tubes has not yet been performed. This work provides a theoretical analysis of the ultrasonic fields within micro-tubes. Numerical results show that for the same tube material, the interaction between the micro-tube and megaHertz-frequency ultrasound may vary drastically with incident frequency, tube diameter and wall thickness. For 10 MHz ultrasonic insonation of a polymethylmethacrylate (PMMA) tube with an inner diameter of 195 μm and an outer diameter of 260 μm, the peak pressure within the tube can be up to 300% of incident pressure amplitude. However, using 1 MHz ultrasound and a silica tube with an inner diameter of 12 μm and an outer diameter of 50 μm, the peak pressure within the tube is only 12% of the incident pressure amplitude and correspondingly, the spatial-average-time-average intensity within the tube is only 1% of the incident intensity. (E-mail: spqin@ucdavis.edu).

Original languageEnglish (US)
Pages (from-to)1014-1020
Number of pages7
JournalUltrasound in Medicine and Biology
Volume34
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Blood vessel phantoms
  • Pressure variation
  • Transmitted ultrasound pressure
  • Ultrasound contrast agents

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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