Transmission of visceral leishmaniasis through blood transfusions from infected English Foxhounds to anemic dogs

Sean D Owens, Donna A. Oakley, Kym Marryott, Wendy Hatchett, Raquel Walton, Tom J. Nolan, Alisa Newton, Frank Steurer, Peter Schantz, Urs Giger

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Objective - To conduct serologic surveillance for Leishmania spp in English Foxhounds from a kennel, as well as recipients of blood from these dogs, and determine whether L infantum organisms could be transmitted via blood transfusion. Design - Serologic prevalence survey. Animals - 120 English Foxhounds and 51 dogs of various breeds receiving blood from these donors. Procedure - Foxhound blood donors, foxhound non-donors, and nonfoxhound blood recipient dogs were evaluated serologically for Leishmania spp by indirect fluorescent antibody testing. Dogs that received packed RBC (PRBC) transfusions from foxhound donors from mid-1996 through mid-2000 were identified. Furthermore, dogs were serologically evaluated if they had received fresh frozen plasma (FFP) transfusions in 1999 and 2000 from seropositive foxhound blood donors. Results - Thirty percent of the English Foxhounds were seropositive for Leishmania spp (titer ≥ 1:16), although the degree of seropositivity varied considerably during the period. Furthermore, 57 foxhounds had been used as donors from 1996 to 2000, and 342 units of PRBC had been transfused to at least 227 patients. All 25 dogs screened that received PRBC from seronegative foxhound donors tested negative, whereas 3 of 7 dogs that received PRBC from seropositive donors tested positive. All 9 dogs that received FFP from seropositive foxhound donors remained seronegative. Conclusions and Clinical Relevance - To our knowledge, this report documents the first transmission of Leishmania spp by blood transfusion. The use of foxhounds as blood donors may not be advisable in North America. (J Am Vet Med Assoc 2001;219: 1081-1088).

Original languageEnglish (US)
Pages (from-to)1076-1083
Number of pages8
JournalJournal of the American Veterinary Medical Association
Volume219
Issue number8
StatePublished - Oct 15 2001
Externally publishedYes

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blood transfusion
visceral leishmaniasis
Visceral Leishmaniasis
Blood Transfusion
Dogs
Leishmania
dogs
Blood Donors
blood
erythrocytes
Tissue Donors
antibody detection
dog breeds
seroprevalence
North America
monitoring
organisms
Antibodies

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Transmission of visceral leishmaniasis through blood transfusions from infected English Foxhounds to anemic dogs. / Owens, Sean D; Oakley, Donna A.; Marryott, Kym; Hatchett, Wendy; Walton, Raquel; Nolan, Tom J.; Newton, Alisa; Steurer, Frank; Schantz, Peter; Giger, Urs.

In: Journal of the American Veterinary Medical Association, Vol. 219, No. 8, 15.10.2001, p. 1076-1083.

Research output: Contribution to journalArticle

Owens, SD, Oakley, DA, Marryott, K, Hatchett, W, Walton, R, Nolan, TJ, Newton, A, Steurer, F, Schantz, P & Giger, U 2001, 'Transmission of visceral leishmaniasis through blood transfusions from infected English Foxhounds to anemic dogs', Journal of the American Veterinary Medical Association, vol. 219, no. 8, pp. 1076-1083.
Owens, Sean D ; Oakley, Donna A. ; Marryott, Kym ; Hatchett, Wendy ; Walton, Raquel ; Nolan, Tom J. ; Newton, Alisa ; Steurer, Frank ; Schantz, Peter ; Giger, Urs. / Transmission of visceral leishmaniasis through blood transfusions from infected English Foxhounds to anemic dogs. In: Journal of the American Veterinary Medical Association. 2001 ; Vol. 219, No. 8. pp. 1076-1083.
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abstract = "Objective - To conduct serologic surveillance for Leishmania spp in English Foxhounds from a kennel, as well as recipients of blood from these dogs, and determine whether L infantum organisms could be transmitted via blood transfusion. Design - Serologic prevalence survey. Animals - 120 English Foxhounds and 51 dogs of various breeds receiving blood from these donors. Procedure - Foxhound blood donors, foxhound non-donors, and nonfoxhound blood recipient dogs were evaluated serologically for Leishmania spp by indirect fluorescent antibody testing. Dogs that received packed RBC (PRBC) transfusions from foxhound donors from mid-1996 through mid-2000 were identified. Furthermore, dogs were serologically evaluated if they had received fresh frozen plasma (FFP) transfusions in 1999 and 2000 from seropositive foxhound blood donors. Results - Thirty percent of the English Foxhounds were seropositive for Leishmania spp (titer ≥ 1:16), although the degree of seropositivity varied considerably during the period. Furthermore, 57 foxhounds had been used as donors from 1996 to 2000, and 342 units of PRBC had been transfused to at least 227 patients. All 25 dogs screened that received PRBC from seronegative foxhound donors tested negative, whereas 3 of 7 dogs that received PRBC from seropositive donors tested positive. All 9 dogs that received FFP from seropositive foxhound donors remained seronegative. Conclusions and Clinical Relevance - To our knowledge, this report documents the first transmission of Leishmania spp by blood transfusion. The use of foxhounds as blood donors may not be advisable in North America. (J Am Vet Med Assoc 2001;219: 1081-1088).",
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