Transmission of lymphadenopathy-associated virus/human T lymphotropic virus type III in sexual partners. Seropositivity does not predict infectivity in all cases

Harold Burger, Barbara Weiser, William S. Robinson, Jeffrey Lifson, Edgar Engleman, Christine Rouzioux, Françoise Brun-Vézinet, Françoise Barré-Sinoussi, Luc Montagnier, Jean Claude Chermann

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

To investigate transmission of lymphadenopathy-associated virus (LAV)/human T lymphotropic virus type III (HTLV-III) in long-term sexual partners, and the relationship between lymphadenopathy-associated virus seropositivity and transmission, nine couples (five heterosexual and four homosexual) at increased risk for acquired immune deficiency syndrome (AIDS) were studied. In two heterosexual couples, transmission of lymphadenopathy-associated virus from a seropositive man at increased risk to his monogamous wife occurred. In one couple, the wife of a man with hemophilia had lymphadenopathy-associated virus antibody and decreased T helper cells; in the other couple, the wife of a bisexual intravenous drug-user had AIDS. Neither woman had a recognized AIDS risk except marriage to a seropositive man at increased risk. However, study of the other couples revealed that regular sexual contact with seropositive persons over long periods did not always lead to evidence of lymphadenopathy-associated virus infection. This study suggests that presence of lymphadenopathy-associated virus antibody does not always indicate a high degree of infectivity.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalThe American journal of medicine
Volume81
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)

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