Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China

Xia Li, Ying Zhang, Xin Shen, Guomiao Shen, Xiaohong Gui, Bin Sun, Jian Mei, Kathryn DeRiemer, Peter M. Small, Qian Gao

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Abstract

We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/ 32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.

Original languageEnglish (US)
Pages (from-to)864-869
Number of pages6
JournalJournal of Infectious Diseases
Volume195
Issue number6
DOIs
StatePublished - Mar 15 2007

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Multidrug-Resistant Tuberculosis
Drug Resistance
China
Mycobacterium tuberculosis
Centers for Disease Control and Prevention (U.S.)
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Li, X., Zhang, Y., Shen, X., Shen, G., Gui, X., Sun, B., ... Gao, Q. (2007). Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China. Journal of Infectious Diseases, 195(6), 864-869. https://doi.org/10.1086/511985

Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China. / Li, Xia; Zhang, Ying; Shen, Xin; Shen, Guomiao; Gui, Xiaohong; Sun, Bin; Mei, Jian; DeRiemer, Kathryn; Small, Peter M.; Gao, Qian.

In: Journal of Infectious Diseases, Vol. 195, No. 6, 15.03.2007, p. 864-869.

Research output: Contribution to journalArticle

Li, X, Zhang, Y, Shen, X, Shen, G, Gui, X, Sun, B, Mei, J, DeRiemer, K, Small, PM & Gao, Q 2007, 'Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China', Journal of Infectious Diseases, vol. 195, no. 6, pp. 864-869. https://doi.org/10.1086/511985
Li, Xia ; Zhang, Ying ; Shen, Xin ; Shen, Guomiao ; Gui, Xiaohong ; Sun, Bin ; Mei, Jian ; DeRiemer, Kathryn ; Small, Peter M. ; Gao, Qian. / Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China. In: Journal of Infectious Diseases. 2007 ; Vol. 195, No. 6. pp. 864-869.
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