Transmission of Creutzfeldt-Jakob Disease to the Stumptail Macaque (Macaco arctoides)

Carlos Espana, D. Carleton Gajdusek, Clarence J. Gibbs, Bennie Osburn, David H. Gribble, George H. Cardinet

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The successful transmission of Creutzfeldt-Jakob disease from both affected human and chimpanzee brain to stumptail macaques has been accomplished. The incubation period of 5 yr was the same for both animals; however, the course of the disease was longer in the animal receiving the human brain. In both cases, initial mild symptoms slowly remitted only to reappear some 4 mo later. Muscle biopsies revealed changes suggestive of a mild neuropathy. In addition, there appeared to be an increased ability to incorporate 3H-thymidine in untreated cultures of lymphocytes from peripheral blood.

Original languageEnglish (US)
Pages (from-to)723-724
Number of pages2
JournalProceedings of the Society for Experimental Biology and Medicine
Volume149
Issue number3
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Transmission of Creutzfeldt-Jakob Disease to the Stumptail Macaque (Macaco arctoides)'. Together they form a unique fingerprint.

  • Cite this