Transmissible murine colonic hyperplasia.

Stephen W Barthold, G. L. Coleman, R. O. Jacoby, E. M. Livestone, A. M. Jonas

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


After exposure to a variant of Citrobacter freundii, suckling and adult mice developed transmissible murine colonic hyperplasia of the same degree of severity. Mucosal hyperplasia was most severe 2 to 3 weeks after inoculation and then regressed. Suckling mice had a high mortality because of secondary inflammatory and erosive changes. Severe hyperplasia was characterized by mitotic activity along the entire crypt column and surface mucosa.

Original languageEnglish (US)
Pages (from-to)223-236
Number of pages14
JournalVeterinary Pathology
Issue number2
StatePublished - Mar 1978
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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