Transmissible Congenital Demyelinating Encephalopathy of Lambs

G. L. Clarke, Bennie Osburn

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Twenty-two fetal lambs were inoculated in utero with tissue suspension prepared from lambs born with weakness, incoordination and clonic tremor. Clinically, affected newborn lambs had clonic tremor, were generally weak and had abnormally pigmented hairy fleece. The inoculation resulted in a disseminated encephalomyelitis with secondary teratologic changes in a significant number of fetuses. The mononuclear inflammatory changes were most obvious 14 days after inoculation, after which there was rapid resolution. Changes seen at birth were chronic astrocytosis with neuron loss in the spinal cord and cerebellar dysplasia. Single radioimmunodiffusion studies showed consistently low IgG in infected fetuses and high IgG in lambs at birth.

Original languageEnglish (US)
Pages (from-to)68-82
Number of pages15
JournalVeterinary Pathology
Volume15
Issue number1
DOIs
StatePublished - Jan 1 1978

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encephalopathy
Brain Diseases
Tremor
Fetus
lambs
Immunoglobulin G
Parturition
Encephalomyelitis
Gliosis
Ataxia
fetus
Spinal Cord
Suspensions
ataxia (disorder)
Neurons
fleece
encephalitis
spinal cord
neonates
neurons

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Transmissible Congenital Demyelinating Encephalopathy of Lambs. / Clarke, G. L.; Osburn, Bennie.

In: Veterinary Pathology, Vol. 15, No. 1, 01.01.1978, p. 68-82.

Research output: Contribution to journalArticle

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