Abstract
Twenty-two fetal lambs were inoculated in utero with tissue suspension prepared from lambs born with weakness, incoordination and clonic tremor. Clinically, affected newborn lambs had clonic tremor, were generally weak and had abnormally pigmented hairy fleece. The inoculation resulted in a disseminated encephalomyelitis with secondary teratologic changes in a significant number of fetuses. The mononuclear inflammatory changes were most obvious 14 days after inoculation, after which there was rapid resolution. Changes seen at birth were chronic astrocytosis with neuron loss in the spinal cord and cerebellar dysplasia. Single radioimmunodiffusion studies showed consistently low IgG in infected fetuses and high IgG in lambs at birth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 68-82 |
| Number of pages | 15 |
| Journal | Veterinary Pathology |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1978 |
Fingerprint
ASJC Scopus subject areas
- veterinary(all)
Cite this
Transmissible Congenital Demyelinating Encephalopathy of Lambs. / Clarke, G. L.; Osburn, Bennie.
In: Veterinary Pathology, Vol. 15, No. 1, 01.01.1978, p. 68-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transmissible Congenital Demyelinating Encephalopathy of Lambs
AU - Clarke, G. L.
AU - Osburn, Bennie
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Twenty-two fetal lambs were inoculated in utero with tissue suspension prepared from lambs born with weakness, incoordination and clonic tremor. Clinically, affected newborn lambs had clonic tremor, were generally weak and had abnormally pigmented hairy fleece. The inoculation resulted in a disseminated encephalomyelitis with secondary teratologic changes in a significant number of fetuses. The mononuclear inflammatory changes were most obvious 14 days after inoculation, after which there was rapid resolution. Changes seen at birth were chronic astrocytosis with neuron loss in the spinal cord and cerebellar dysplasia. Single radioimmunodiffusion studies showed consistently low IgG in infected fetuses and high IgG in lambs at birth.
AB - Twenty-two fetal lambs were inoculated in utero with tissue suspension prepared from lambs born with weakness, incoordination and clonic tremor. Clinically, affected newborn lambs had clonic tremor, were generally weak and had abnormally pigmented hairy fleece. The inoculation resulted in a disseminated encephalomyelitis with secondary teratologic changes in a significant number of fetuses. The mononuclear inflammatory changes were most obvious 14 days after inoculation, after which there was rapid resolution. Changes seen at birth were chronic astrocytosis with neuron loss in the spinal cord and cerebellar dysplasia. Single radioimmunodiffusion studies showed consistently low IgG in infected fetuses and high IgG in lambs at birth.
UR - http://www.scopus.com/inward/record.url?scp=0017799335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017799335&partnerID=8YFLogxK
U2 - 10.1177/030098587801500109
DO - 10.1177/030098587801500109
M3 - Article
C2 - 625870
AN - SCOPUS:0017799335
VL - 15
SP - 68
EP - 82
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
IS - 1
ER -