Translational toxicology in zebrafish

Tamara Tal, Bianca Yaghoobi, Pamela J. Lein

Research output: Contribution to journalReview article

Abstract

A major goal of translational toxicology is to identify adverse chemical effects and determine whether they are conserved or divergent across experimental systems. Translational toxicology encompasses assessment of chemical toxicity across multiple life stages, determination of toxic mode of action, computational prediction modeling, and identification of interventions that protect or restore health after toxic chemical exposures. The zebrafish is increasingly used in translational toxicology because it combines the genetic and physiological advantages of mammalian models with the higher-throughput capabilities and genetic manipulability of invertebrate models. Here, we review the recent literature demonstrating the power of the zebrafish as a model for addressing all four activities of translational toxicology. Important data gaps and challenges associated with using zebrafish for translational toxicology are also discussed.

Original languageEnglish (US)
Pages (from-to)56-66
Number of pages11
JournalCurrent Opinion in Toxicology
Volume23-24
DOIs
StatePublished - Oct 1 2020

Keywords

  • Gut microbiome
  • Hazard identification
  • Interventions
  • Life stages
  • Mode of action
  • Predictive toxicity

ASJC Scopus subject areas

  • Toxicology

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