Translational Stroke Research in the Developing Brain

Zinaida S. Vexler, Frank R Sharp, Giora Z. Feuerstein, Stephen Ashwal, Marianne Thoresen, Jerome Y. Yager, Donna M. Ferriero

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Preclinical animal models can help guide the development of clinical pediatric and newborn stroke trials. Data obtained using currently available models of hypoxia-ischemia and focal stroke have demonstrated the need for age-appropriate models. There are age-related differences in susceptibility of the immature brain to oxidative stress and inflammation, as well as in the rate and degree of apoptotic neuronal death. These issues need to be carefully addressed in designing future clinical trials.

Original languageEnglish (US)
Pages (from-to)459-463
Number of pages5
JournalPediatric Neurology
Volume34
Issue number6
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

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