Translational Stroke Research in the Developing Brain

Zinaida S. Vexler, Frank R Sharp, Giora Z. Feuerstein, Stephen Ashwal, Marianne Thoresen, Jerome Y. Yager, Donna M. Ferriero

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Preclinical animal models can help guide the development of clinical pediatric and newborn stroke trials. Data obtained using currently available models of hypoxia-ischemia and focal stroke have demonstrated the need for age-appropriate models. There are age-related differences in susceptibility of the immature brain to oxidative stress and inflammation, as well as in the rate and degree of apoptotic neuronal death. These issues need to be carefully addressed in designing future clinical trials.

Original languageEnglish (US)
Pages (from-to)459-463
Number of pages5
JournalPediatric Neurology
Issue number6
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology


Dive into the research topics of 'Translational Stroke Research in the Developing Brain'. Together they form a unique fingerprint.

Cite this