Translational mouse models of autism: Advancing toward pharmacological therapeutics

Tatiana M. Kazdoba, Prescott T. Leach, Mu Yang, Jill L Silverman, Marjorie Solomon Friedman, Jacqueline Crawley

Research output: Chapter in Book/Report/Conference proceedingChapter

50 Scopus citations

Abstract

Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been generated for many of the de novo single gene mutations and copy number variants (CNVs) detected in ASD and comorbid neurodevelopmental disorders. Mouse models incorporating genetic and environmental manipulations have been employed for preclinical testing of hypothesis-driven pharmacological targets, to begin to develop treatments for the diagnostic and associated symptoms of autism. In this review, we summarize rodent behavioral assays relevant to the core features of autism, preclinical and clinical evaluations of pharmacological interventions, and strategies to improve the translational value of rodent models of autism.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Behavioral Neurosciences
PublisherSpringer Verlag
Pages1-52
Number of pages52
Volume28
DOIs
StatePublished - Jan 1 2016

Publication series

NameCurrent Topics in Behavioral Neurosciences
Volume28
ISSN (Print)18663370
ISSN (Electronic)18663389

Keywords

  • Autism
  • Clinical trials
  • Cognition
  • Construct validity
  • Face validity
  • Genes
  • Mice
  • Mouse
  • Mutant models
  • Pharmacological treatment
  • Preclinical
  • Predictive validity
  • Rats
  • Repetitive behavior
  • Sociability
  • Social behavior
  • Translational
  • Ultrasonic vocalization

ASJC Scopus subject areas

  • Medicine(all)
  • Behavioral Neuroscience

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  • Cite this

    Kazdoba, T. M., Leach, P. T., Yang, M., Silverman, J. L., Friedman, M. S., & Crawley, J. (2016). Translational mouse models of autism: Advancing toward pharmacological therapeutics. In Current Topics in Behavioral Neurosciences (Vol. 28, pp. 1-52). (Current Topics in Behavioral Neurosciences; Vol. 28). Springer Verlag. https://doi.org/10.1007/7854_2015_5003