Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy

Bevin Lin; Shiro Urayama; Ramez M G Saroufeem; Dennis L Matthews; Stavros G. Demos

doi:10.1117/12.871718

Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy

Bevin Lin, Shiro Urayama, Ramez M G Saroufeem, Dennis L Matthews, Stavros G. Demos

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The potential of autofluorescence microscopy under ultraviolet excitation is investigated as a method to visualize superficial epithelial microstructures and their modification with progression of disease. This method does not require the use of contrast agents, sectioning methods, or tissue preparation. Imaging of esophagus tissue is the focus of this study and deals with three main issues: a) What is the origin of the signal; b) How the gradual microstructure modification associated with various stages of esophageal disease is visualized; c) What are the designing parameters for in vivo implementation.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7895
DOIs	https://doi.org/10.1117/12.871718
State	Published - 2011
Event	Optical Biopsy IX - San Francisco, CA, United States Duration: Jan 24 2011 → Jan 26 2011

Other

Other	Optical Biopsy IX
Country	United States
City	San Francisco, CA
Period	1/24/11 → 1/26/11

Keywords

autofluorescence
Endoscopy
gastrointestinal
microscopy
real-time diagnostic imaging

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.871718

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Cite this

Lin, B., Urayama, S., Saroufeem, R. M. G., Matthews, D. L., & Demos, S. G. (2011). Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7895). [789502] https://doi.org/10.1117/12.871718

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AB - The potential of autofluorescence microscopy under ultraviolet excitation is investigated as a method to visualize superficial epithelial microstructures and their modification with progression of disease. This method does not require the use of contrast agents, sectioning methods, or tissue preparation. Imaging of esophagus tissue is the focus of this study and deals with three main issues: a) What is the origin of the signal; b) How the gradual microstructure modification associated with various stages of esophageal disease is visualized; c) What are the designing parameters for in vivo implementation.

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