Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy

Bevin Lin, Shiro Urayama, Ramez M G Saroufeem, Dennis L Matthews, Stavros G. Demos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The potential of autofluorescence microscopy under ultraviolet excitation is investigated as a method to visualize superficial epithelial microstructures and their modification with progression of disease. This method does not require the use of contrast agents, sectioning methods, or tissue preparation. Imaging of esophagus tissue is the focus of this study and deals with three main issues: a) What is the origin of the signal; b) How the gradual microstructure modification associated with various stages of esophageal disease is visualized; c) What are the designing parameters for in vivo implementation.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7895
DOIs
StatePublished - 2011
EventOptical Biopsy IX - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Other

OtherOptical Biopsy IX
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Keywords

  • autofluorescence
  • Endoscopy
  • gastrointestinal
  • microscopy
  • real-time diagnostic imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Lin, B., Urayama, S., Saroufeem, R. M. G., Matthews, D. L., & Demos, S. G. (2011). Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7895). [789502] https://doi.org/10.1117/12.871718