Translating metabolic reprogramming into new targets for kidney cancer

Omran Abu Aboud, Robert H. Weiss

Research output: Contribution to journalReview articlepeer-review

Abstract

In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered. Whereas a generation ago, investigators would study their “favorite” protein or gene and exhaustively catalog the role of this compound in their disease of interest, the appearance of omics has changed the face of medicine such that much of the cutting edge (and fundable!) medical research now evaluates the biology of the disease nearly in its entirety. Couple this with the realization that kidney cancer is a “metabolic disease” due to its multiple derangements in biochemical pathways [1, 2], and clear cell renal cell carcinoma (ccRCC) becomes ripe for data mining using multiple omics approaches.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalKidney Cancer
Volume1
Issue number2
DOIs
StatePublished - 2017

Keywords

  • Kidney cancer
  • Metabolomics
  • Reprogramming
  • Therapeutic targets

ASJC Scopus subject areas

  • Nephrology
  • Oncology

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