Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy

A. B. Mukherjee, A. Ghazanfari, S. Svoronos, R. C. Staton, T. Nakada, Ingrid Kwee

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Abstract

We studied a thiamine-dependent enzyme, transketolase, from fibroblasts of a diabetic patient who developed Wernicke's encephalopathy when treated with tolazamide, in order to delineate if this patient also had transketolase abnormality [high K(m) for thiamine pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsakoff syndrome. In addition to this patient, we also studied this enzyme from three diabetic kindreds without any history of Wernicke's encephalopathy and from four normal controls. We found that the above-mentioned patient and one of the diabetic kindreds with no history of Wernicke's encephalopathy had abnormal transketolase as determined by its K(m) for TPP. These data suggest a similarity between postalcoholic Wernicke-Korsakoff syndrome and the patient with tolazamide-induced Wernicke's encephalopathy from the standpoint of transketolase abnormality.

Original languageEnglish (US)
Pages (from-to)1508-1510
Number of pages3
JournalNeurology
Volume36
Issue number11
StatePublished - 1986

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Tolazamide
Wernicke Encephalopathy
Transketolase
Korsakoff Syndrome
Thiamine Pyrophosphate
Thiamine
Enzymes
Fibroblasts

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mukherjee, A. B., Ghazanfari, A., Svoronos, S., Staton, R. C., Nakada, T., & Kwee, I. (1986). Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy. Neurology, 36(11), 1508-1510.

Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy. / Mukherjee, A. B.; Ghazanfari, A.; Svoronos, S.; Staton, R. C.; Nakada, T.; Kwee, Ingrid.

In: Neurology, Vol. 36, No. 11, 1986, p. 1508-1510.

Research output: Contribution to journalArticle

Mukherjee, AB, Ghazanfari, A, Svoronos, S, Staton, RC, Nakada, T & Kwee, I 1986, 'Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy', Neurology, vol. 36, no. 11, pp. 1508-1510.
Mukherjee AB, Ghazanfari A, Svoronos S, Staton RC, Nakada T, Kwee I. Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy. Neurology. 1986;36(11):1508-1510.
Mukherjee, A. B. ; Ghazanfari, A. ; Svoronos, S. ; Staton, R. C. ; Nakada, T. ; Kwee, Ingrid. / Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy. In: Neurology. 1986 ; Vol. 36, No. 11. pp. 1508-1510.
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AU - Nakada, T.

AU - Kwee, Ingrid

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N2 - We studied a thiamine-dependent enzyme, transketolase, from fibroblasts of a diabetic patient who developed Wernicke's encephalopathy when treated with tolazamide, in order to delineate if this patient also had transketolase abnormality [high K(m) for thiamine pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsakoff syndrome. In addition to this patient, we also studied this enzyme from three diabetic kindreds without any history of Wernicke's encephalopathy and from four normal controls. We found that the above-mentioned patient and one of the diabetic kindreds with no history of Wernicke's encephalopathy had abnormal transketolase as determined by its K(m) for TPP. These data suggest a similarity between postalcoholic Wernicke-Korsakoff syndrome and the patient with tolazamide-induced Wernicke's encephalopathy from the standpoint of transketolase abnormality.

AB - We studied a thiamine-dependent enzyme, transketolase, from fibroblasts of a diabetic patient who developed Wernicke's encephalopathy when treated with tolazamide, in order to delineate if this patient also had transketolase abnormality [high K(m) for thiamine pyrophosphate (TPP)], as previously reported in postalcoholic Wernicke-Korsakoff syndrome. In addition to this patient, we also studied this enzyme from three diabetic kindreds without any history of Wernicke's encephalopathy and from four normal controls. We found that the above-mentioned patient and one of the diabetic kindreds with no history of Wernicke's encephalopathy had abnormal transketolase as determined by its K(m) for TPP. These data suggest a similarity between postalcoholic Wernicke-Korsakoff syndrome and the patient with tolazamide-induced Wernicke's encephalopathy from the standpoint of transketolase abnormality.

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