Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques

Monica Vaccari, Claudio Fenizia, Zhong Min Ma, Anna Hryniewicz, Adriano Boasso, Melvin N. Doster, Chris J Miller, Niklas Lindegardh, Joel Tarning, Alan L. Landay, Gene M. Shearer, Genoveffa Franchini

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down-regulation of innate acute responses to the virus within a few weeks of infection and results in limited pathology. Chloroquine (CQ) has been used in the treatment or prevention of malaria and has recently been shown to cause a decrease of immune activation and CD4 cell loss in HIV-infected individuals treated with antiretroviral therapy. Here, we treated Rhesus macaques with CQ during the acute phase of SIVmac251 infection with the intent to decrease viral-induced immune activation and possibly limit disease progression. Contrary to what was expected, CQ treatment resulted in a temporary increased expression of interferon (IFN)-stimulating genes and it worsened the recovery of CD4 + T cells in the blood. Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)355-362
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume30
Issue number4
DOIs
StatePublished - Apr 1 2014

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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    Vaccari, M., Fenizia, C., Ma, Z. M., Hryniewicz, A., Boasso, A., Doster, M. N., Miller, C. J., Lindegardh, N., Tarning, J., Landay, A. L., Shearer, G. M., & Franchini, G. (2014). Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques. AIDS Research and Human Retroviruses, 30(4), 355-362. https://doi.org/10.1089/aid.2013.0218