Transhepatic fibrinolysis of mesenteric and portal vein thrombosis in a patient with ulcerative colitis: A case report

Alfredo Guglielmi, Francesca Fior, Orsolya Halmos, Gian Franco Veraldi, Lorenzo Rossaro, Andrea Ruzzenente, Claudio Cordiano

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Aim: To present a case of acute mesenteric and portal vein thrombosis treated with thrombolytic therapy in a patient with ulcerative colitis in acute phase and to review the literature on thrombolytic therapy of mesenteric-portal system. Treatment of acute portal vein thrombosis has ranged from conservative treatment with thrombolysis and anticoagulation therapy to surgical treatment with thrombectomy and/or intestinal resection. Methods: We treated our patient with intraportal infusion of plasminogen activator and then heparin through a percutaneous transhepatic catheter. Results: Thrombus resolved despite premature interruption of the thrombolytic treatment for neurological complications, which subsequently resolved. Conclusion: Conservative management with plasminogen activator, could be considered as a good treatment for patients with acute porto-mesenteric thrombosis.

Original languageEnglish (US)
Pages (from-to)2035-2038
Number of pages4
JournalWorld Journal of Gastroenterology
Volume11
Issue number13
StatePublished - Apr 7 2005

Keywords

  • Acute mesenteric
  • Portal vein thrombosis

ASJC Scopus subject areas

  • Gastroenterology

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