Transgenic mouse models of mammary tumorigenesis

Robert Cardiff, W. J. Muller

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

Transgenic mice have been used as models for the molecular analysis of mammary tumorigenesis for almost a decade. During this period, the introduction of specific oncogenes into the mouse genome has established their role in the development of mammary tumours. Most oncogenes result in gradual, stochastic neoplastic progression with high levels of transgene expression in the neoplasms. The transgenes appear to induce tumours with unique histological patterns that are specific for the particular oncogene. In these cases, in vivo oncogene mediated neoplastic progression is clearly complex and requires the co-operation of two or more genetic elements. Polyomavirus middle T and activated neu, both activated tyrosine kinases, are potential exceptions to this type of mechanism, since they appear to be capable of inducing rapid neoplastic progression, including metastatic disease, once transgene expression reaches a critical threshold. Transgenic mice are now being used to analyse the underlying molecular biology. The application of new technologies such as proviral tagging and site specific recombination in embryonic stem cells offers other approaches for studying proliferation in vivo. A more detailed understanding of events in the mouse will lead to the application of our knowledge to human breast cancer.

Original languageEnglish (US)
Pages (from-to)97-113
Number of pages17
JournalCancer Surveys
Volume16
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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