Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors

T. Jake Liang, Andrea E. Reid, Ramnik Xavier, Robert Cardiff, Timothy C. Wang

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse roles in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis.

Original languageEnglish (US)
Pages (from-to)2872-2877
Number of pages6
JournalJournal of Clinical Investigation
Volume97
Issue number12
DOIs
StatePublished - Jun 15 1996

Fingerprint

Hepatocyte Growth Factor
Receptor Protein-Tyrosine Kinases
Oncogenes
Hyperplasia
Breast Neoplasms
Cell Shape
Protein-Tyrosine Kinases
Transgenic Mice
Cell Movement
Signal Transduction
Carcinogenesis
Breast
Ligands
Growth
Neoplasms
In Vitro Techniques

Keywords

  • c-met
  • carcinogenesis
  • hepatocyte growth factor
  • receptor tyrosine kinase
  • sarcoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. / Liang, T. Jake; Reid, Andrea E.; Xavier, Ramnik; Cardiff, Robert; Wang, Timothy C.

In: Journal of Clinical Investigation, Vol. 97, No. 12, 15.06.1996, p. 2872-2877.

Research output: Contribution to journalArticle

Liang, T. Jake ; Reid, Andrea E. ; Xavier, Ramnik ; Cardiff, Robert ; Wang, Timothy C. / Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. In: Journal of Clinical Investigation. 1996 ; Vol. 97, No. 12. pp. 2872-2877.
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