Transgenerational effects of binge drinking in a primate model: Implications for human health

Catherine A. Vandevoort, Kristin N Grimsrud, Uros Midic, Namdori Mtango, Keith E. Latham

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development. Design Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating. Setting National primate research center. Animal(s) Adult female rhesus monkeys. Intervention(s) Binge levels of ethanol, given twice weekly for 6 months before a standard in vitro fertilization cycle with or without embryo culture. With in vivo development, ethanol treatment continued until pregnancy was identified. Main Outcome Measure(s) Oocyte and cumulus/granulosa cell gene expression, embryo development to blastocyst, and pregnancy rate. Result(s) Embryo development in vitro was reduced; changes were found in oocyte and cumulus cell gene expression; and spontaneous abortion during very early gestation increased. Conclusion(s) This study provides evidence that binge drinking can affect the developmental potential of oocytes even after alcohol consumption has ceased.

Original languageEnglish (US)
Pages (from-to)560-569
Number of pages10
JournalFertility and Sterility
Volume103
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Binge Drinking
Primates
Oocytes
Ethanol
Cumulus Cells
Embryonic Development
Health
Fertilization in Vitro
Gene Expression
Pregnancy
Blastocyst
Spontaneous Abortion
Pregnancy Rate
Ovulation
Macaca mulatta
Alcohol Drinking
Embryonic Structures
Outcome Assessment (Health Care)
Research

Keywords

  • cDNA array
  • Cumulus cells
  • fetal alcohol syndrome
  • granulosa cells
  • reproduction
  • transcriptome

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Transgenerational effects of binge drinking in a primate model : Implications for human health. / Vandevoort, Catherine A.; Grimsrud, Kristin N; Midic, Uros; Mtango, Namdori; Latham, Keith E.

In: Fertility and Sterility, Vol. 103, No. 2, 01.02.2015, p. 560-569.

Research output: Contribution to journalArticle

Vandevoort, Catherine A. ; Grimsrud, Kristin N ; Midic, Uros ; Mtango, Namdori ; Latham, Keith E. / Transgenerational effects of binge drinking in a primate model : Implications for human health. In: Fertility and Sterility. 2015 ; Vol. 103, No. 2. pp. 560-569.
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