Abstract
Microchimerism, the stable persistence of an allogeneic cell population, can result from allogeneic exposures including blood transfusion. Transfusion-associated microchimerism (TA-MC) appears to be a common but newly recognized complication of blood transfusion. Thus far TA-MC has been detected when severely injured patients are transfused. Injury induces an immunosuppressive and inflammatory milieu in which fresh blood products with replication-competent leukocytes can sometimes cause TA-MC. TA-MC is present in approximately half of transfused severely injured patients at hospital discharge and is not affected by leukoreduction. In approximately 10% of patients, the chimerism from a single blood donor may increase in magnitude over months to years, reaching as much as 2% to 5% of all circulating leukocytes. In this review, we discuss recent studies of TA-MC in the civilian trauma population and the potential for study of TA-MC in the military population, where the severity of injury and freshness of blood products suggest that TA-MC may be even more prominent. We also discuss the need for future studies to address the immunology of TA-MC, its stem cell biology, and its clinical manifestations that have the potential to be either pathologic (autoimmunity, graft-versus-host disease) or therapeutic (tolerance induction, various cell and gene therapies).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 24-31 |
| Number of pages | 8 |
| Journal | Seminars in Hematology |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2007 |
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ASJC Scopus subject areas
- Hematology
Cite this
Transfusion-Associated Microchimerism : A New Complication of Blood Transfusions in Severely Injured Patients. / Reed, William; Lee, Tzong Hae; Norris, Philip J.; Utter, Garth H; Busch, Michael P.
In: Seminars in Hematology, Vol. 44, No. 1, 01.2007, p. 24-31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transfusion-Associated Microchimerism
T2 - A New Complication of Blood Transfusions in Severely Injured Patients
AU - Reed, William
AU - Lee, Tzong Hae
AU - Norris, Philip J.
AU - Utter, Garth H
AU - Busch, Michael P.
PY - 2007/1
Y1 - 2007/1
N2 - Microchimerism, the stable persistence of an allogeneic cell population, can result from allogeneic exposures including blood transfusion. Transfusion-associated microchimerism (TA-MC) appears to be a common but newly recognized complication of blood transfusion. Thus far TA-MC has been detected when severely injured patients are transfused. Injury induces an immunosuppressive and inflammatory milieu in which fresh blood products with replication-competent leukocytes can sometimes cause TA-MC. TA-MC is present in approximately half of transfused severely injured patients at hospital discharge and is not affected by leukoreduction. In approximately 10% of patients, the chimerism from a single blood donor may increase in magnitude over months to years, reaching as much as 2% to 5% of all circulating leukocytes. In this review, we discuss recent studies of TA-MC in the civilian trauma population and the potential for study of TA-MC in the military population, where the severity of injury and freshness of blood products suggest that TA-MC may be even more prominent. We also discuss the need for future studies to address the immunology of TA-MC, its stem cell biology, and its clinical manifestations that have the potential to be either pathologic (autoimmunity, graft-versus-host disease) or therapeutic (tolerance induction, various cell and gene therapies).
AB - Microchimerism, the stable persistence of an allogeneic cell population, can result from allogeneic exposures including blood transfusion. Transfusion-associated microchimerism (TA-MC) appears to be a common but newly recognized complication of blood transfusion. Thus far TA-MC has been detected when severely injured patients are transfused. Injury induces an immunosuppressive and inflammatory milieu in which fresh blood products with replication-competent leukocytes can sometimes cause TA-MC. TA-MC is present in approximately half of transfused severely injured patients at hospital discharge and is not affected by leukoreduction. In approximately 10% of patients, the chimerism from a single blood donor may increase in magnitude over months to years, reaching as much as 2% to 5% of all circulating leukocytes. In this review, we discuss recent studies of TA-MC in the civilian trauma population and the potential for study of TA-MC in the military population, where the severity of injury and freshness of blood products suggest that TA-MC may be even more prominent. We also discuss the need for future studies to address the immunology of TA-MC, its stem cell biology, and its clinical manifestations that have the potential to be either pathologic (autoimmunity, graft-versus-host disease) or therapeutic (tolerance induction, various cell and gene therapies).
UR - http://www.scopus.com/inward/record.url?scp=33845749097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845749097&partnerID=8YFLogxK
U2 - 10.1053/j.seminhematol.2006.09.012
DO - 10.1053/j.seminhematol.2006.09.012
M3 - Article
C2 - 17198844
AN - SCOPUS:33845749097
VL - 44
SP - 24
EP - 31
JO - Seminars in Hematology
JF - Seminars in Hematology
SN - 0037-1963
IS - 1
ER -