Transfusion-associated graft-versus-host disease

Denis M Dwyre, P. V. Holland

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of transfusion of cellular blood components producing a graft-versus-host clinical picture with concomitant bone marrow aplasia. The disease is fulminant and rapidly fatal in the majority of patients. TA-GvHD is caused by transfused blood-derived, alloreactive T lymphocytes that attack host tissue, including bone marrow with resultant bone marrow failure. Human leucocyte antigen similarity between the transfused lymphocytes and the host, often in conjunction with host immunosuppression, allows tolerance of the grafted lymphocytes to survive the host immunological response. Any blood component containing viable T lymphocytes can cause TA-GvHD, with fresher components more likely to have intact cells and, thus, able to cause disease. Treatment is generally not helpful, while prevention, usually via irradiation of blood components given to susceptible recipients, is the key to obviating TA-GvHD. Newer methods, such as pathogen inactivation, may play an important role in the future.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalVox Sanguinis
Volume95
Issue number2
DOIs
StatePublished - Aug 2008

Fingerprint

Graft vs Host Disease
Bone Marrow
Blood Component Transfusion
Lymphocytes
T-Lymphocytes
HLA Antigens
Immunosuppression
Transplants
Therapeutics

Keywords

  • Graft-versus-host
  • Immunosuppression
  • Irradiation
  • Transfusion

ASJC Scopus subject areas

  • Hematology

Cite this

Transfusion-associated graft-versus-host disease. / Dwyre, Denis M; Holland, P. V.

In: Vox Sanguinis, Vol. 95, No. 2, 08.2008, p. 85-93.

Research output: Contribution to journalArticle

Dwyre, Denis M ; Holland, P. V. / Transfusion-associated graft-versus-host disease. In: Vox Sanguinis. 2008 ; Vol. 95, No. 2. pp. 85-93.
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