Transforming growth factor β (TGF-β) and autoimmunity

Christopher A. Aoki, Andrea T. Borchers, Ming Li, Richard A. Flavell, Christopher Bowlus, Aftab A. Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

TGF-β1 deficient mice develop multifocal inflammatory autoimmune disease and serve as a valuable animal model of autoimmunity. Transgenic expression of a dominant negative form of TGF-β receptor type II in T cells have enabled the study of cell lineage specific effects of TGF-β providing clues to the potential etiology of autoimmunity. These studies suggest that TGF-β deficiency may induce autoimmune disease by influencing a number of immunological phenomena including lymphocyte activation and differentiation, cell adhesion molecule expression, regulatory T cell function, the expression of MHC molecules and cytokines, and cell apoptosis. The spectrum of effects appears to be significant in mucosal immunity and may contribute to the pathogenesis of inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)450-459
Number of pages10
JournalAutoimmunity Reviews
Volume4
Issue number7
DOIs
StatePublished - Sep 2005

Fingerprint

Transforming Growth Factors
Autoimmunity
Autoimmune Diseases
Mucosal Immunity
Growth Factor Receptors
Cell Adhesion Molecules
Cell Lineage
Regulatory T-Lymphocytes
Lymphocyte Activation
Inflammatory Bowel Diseases
Animal Models
Apoptosis
Cytokines
T-Lymphocytes

Keywords

  • Animal models
  • Autoimmunity
  • Dominant negative TGF-β receptor type II
  • Pathophysiology
  • TGF-β

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Transforming growth factor β (TGF-β) and autoimmunity. / Aoki, Christopher A.; Borchers, Andrea T.; Li, Ming; Flavell, Richard A.; Bowlus, Christopher; Ansari, Aftab A.; Gershwin, M. Eric.

In: Autoimmunity Reviews, Vol. 4, No. 7, 09.2005, p. 450-459.

Research output: Contribution to journalArticle

Aoki, Christopher A. ; Borchers, Andrea T. ; Li, Ming ; Flavell, Richard A. ; Bowlus, Christopher ; Ansari, Aftab A. ; Gershwin, M. Eric. / Transforming growth factor β (TGF-β) and autoimmunity. In: Autoimmunity Reviews. 2005 ; Vol. 4, No. 7. pp. 450-459.
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