Transfer of experimental allergic neuritis with P2-reactive T-cell lines

Abdolmohammad Rostami, James B. Burns, Mark J. Brown, Janet Rosen, Burton Zweiman, Robert P. Lisak, David E Pleasure

Research output: Contribution to journalArticle

Abstract

Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.

Original languageEnglish (US)
Pages (from-to)354-361
Number of pages8
JournalCellular Immunology
Volume91
Issue number2
DOIs
StatePublished - Apr 1 1985
Externally publishedYes

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Experimental Autoimmune Neuritis
T-Lymphocytes
Cell Line
Anti-Idiotypic Antibodies
Adoptive Transfer
Antibody Formation
Phenotype
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Rostami, A., Burns, J. B., Brown, M. J., Rosen, J., Zweiman, B., Lisak, R. P., & Pleasure, D. E. (1985). Transfer of experimental allergic neuritis with P2-reactive T-cell lines. Cellular Immunology, 91(2), 354-361. https://doi.org/10.1016/0008-8749(85)90233-3

Transfer of experimental allergic neuritis with P2-reactive T-cell lines. / Rostami, Abdolmohammad; Burns, James B.; Brown, Mark J.; Rosen, Janet; Zweiman, Burton; Lisak, Robert P.; Pleasure, David E.

In: Cellular Immunology, Vol. 91, No. 2, 01.04.1985, p. 354-361.

Research output: Contribution to journalArticle

Rostami, A, Burns, JB, Brown, MJ, Rosen, J, Zweiman, B, Lisak, RP & Pleasure, DE 1985, 'Transfer of experimental allergic neuritis with P2-reactive T-cell lines', Cellular Immunology, vol. 91, no. 2, pp. 354-361. https://doi.org/10.1016/0008-8749(85)90233-3
Rostami A, Burns JB, Brown MJ, Rosen J, Zweiman B, Lisak RP et al. Transfer of experimental allergic neuritis with P2-reactive T-cell lines. Cellular Immunology. 1985 Apr 1;91(2):354-361. https://doi.org/10.1016/0008-8749(85)90233-3
Rostami, Abdolmohammad ; Burns, James B. ; Brown, Mark J. ; Rosen, Janet ; Zweiman, Burton ; Lisak, Robert P. ; Pleasure, David E. / Transfer of experimental allergic neuritis with P2-reactive T-cell lines. In: Cellular Immunology. 1985 ; Vol. 91, No. 2. pp. 354-361.
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