Transfer of experimental allergic neuritis with P2-reactive T-cell lines

Abdolmohammad Rostami, James B. Burns, Mark J. Brown, Janet Rosen, Burton Zweiman, Robert P. Lisak, David E Pleasure

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.

Original languageEnglish (US)
Pages (from-to)354-361
Number of pages8
JournalCellular Immunology
Volume91
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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    Rostami, A., Burns, J. B., Brown, M. J., Rosen, J., Zweiman, B., Lisak, R. P., & Pleasure, D. E. (1985). Transfer of experimental allergic neuritis with P2-reactive T-cell lines. Cellular Immunology, 91(2), 354-361. https://doi.org/10.1016/0014-2999(85)90752-6