Transfer of experimental allergic neuritis with P2-reactive T-cell lines

Abdolmohammad Rostami; James B. Burns; Mark J. Brown; Janet Rosen; Burton Zweiman; Robert P. Lisak; David E Pleasure

doi:10.1016/0014-2999(85)90752-6

Transfer of experimental allergic neuritis with P₂-reactive T-cell lines

Abdolmohammad Rostami, James B. Burns, Mark J. Brown, Janet Rosen, Burton Zweiman, Robert P. Lisak, David E Pleasure

Research output: Contribution to journal › Article

77 Scopus citations

Abstract

Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P₂ protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P₂ antibody response in the recipients of the P₂-reactive cells recovered from donors with high anti-P₂ antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P₂ antibody in passive EAN.

Original language	English (US)
Pages (from-to)	354-361
Number of pages	8
Journal	Cellular Immunology
Volume	91
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(85)90752-6
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Immunology

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Rostami, A., Burns, J. B., Brown, M. J., Rosen, J., Zweiman, B., Lisak, R. P., & Pleasure, D. E. (1985). Transfer of experimental allergic neuritis with P₂-reactive T-cell lines. Cellular Immunology, 91(2), 354-361. https://doi.org/10.1016/0014-2999(85)90752-6

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abstract = "Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.",

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AU - Rostami, Abdolmohammad

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AU - Brown, Mark J.

AU - Rosen, Janet

AU - Zweiman, Burton

AU - Lisak, Robert P.

AU - Pleasure, David E

PY - 1985

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AB - Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.

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