Transfer of experimental allergic neuritis with P2-reactive T-cell lines

Abdolmohammad Rostami, James B. Burns, Mark J. Brown, Janet Rosen, Burton Zweiman, Robert P. Lisak, David E Pleasure

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Experimental allergic neuritis (EAN) was induced in normal Lewis rats by systemic passive transfer of T-cell lines responding to P2 protein. These cells had predominantly helper phenotype and could induce EAN within 7 days following adoptive transfer. There was no anti-P2 antibody response in the recipients of the P2-reactive cells recovered from donors with high anti-P2 antibody levels. This study provides direct evidence that T cells are important for the induction of EAN. Furthermore, there was no evidence of a pathogenic role for anti-P2 antibody in passive EAN.

Original languageEnglish (US)
Pages (from-to)354-361
Number of pages8
JournalCellular Immunology
Issue number2
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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