Objective To compare the accuracy of transcutaneous (tc) to arterial partial pressure of carbon dioxide (PaCO 2) and partial pressure of oxygen (PaO 2) in anesthetized rabbits. Study design Prospective, randomized, experimental study. Animals Eight healthy adult female New Zealand white rabbits weighing 4.05±0.30kg. Methods Isoflurane anesthetized rabbits received six treatments in random order; PaCO 2<35, 35-45, and >45mmHg and PaO 2<80, 100-200, >200mmHg. Arterial and transcutaneous measurements were taken after 15minutes of stabilization at each condition. Linear regression, correlation and Bland-Altman analysis were performed to compare PtcCO 2 to PaCO 2 and PtcO 2 to PaO 2. Results Over a range of measured PaCO 2 values from 21 to 67mmHg (n=24) mean bias for PtcCO 2 was -1mmHg and the 95% limits of agreement were -7 to 5mmHg. The correlation between PtcCO 2 and PaCO 2 was strong with R 2 value of 0.9454. Over the entire range of measured PaO 2 values (46-508mmHg) mean bias for PtcO 2 was -61mmHg and the 95% limits of agreement were -226 to 104mmHg. Correlation was poor with R 2=0.5969. Comparing PtcO 2 to PaO 2 over a narrower range [PaO 2<150mmHg (n=13)] improved the correlation, with an R 2 value of 0.8518, mean bias of -7mmHg and 95% limits of agreement from -33 to 19mmHg. Conclusions and clinical relevance In healthy anesthetized rabbits, PtcCO 2 closely approximated PaCO 2. In contrast PtcO 2 underestimated PaO 2, particularly at high values. The PtcCO 2 sensor may be a useful noninvasive way to assess adequacy of ventilation in anesthetized rabbits.
- Blood gas monitoring
- Transcutaneous blood gas
- Transcutaneous carbon dioxide
- Transcutaneous oxygen
ASJC Scopus subject areas