Transcriptional profiles of Treponema denticola in response to environmental conditions

Ian Howard Mchardy, Caroline Keegan, Jee Hyun Sim, Wenyuan Shi, Renate Lux

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The periodontal pathogen T. denticola resides in a stressful environment rife with challenges, the human oral cavity. Knowledge of the stress response capabilities of this invasive spirochete is currently very limited. Whole genome expression profiles in response to different suspected stresses including heat shock, osmotic downshift, oxygen and blood exposure were examined. Most of the genes predicted to encode conserved heat shock proteins (HSPs) were found to be induced under heat and oxygen stress. Several of these HSPs also seem to be important for survival in hypotonic solutions and blood. In addition to HSPs, differential regulation of many genes encoding metabolic proteins, hypothetical proteins, transcriptional regulators and transporters was observed in patterns that could betoken functional associations. In summary, stress responses in T. denticola exhibit many similarities to the corresponding stress responses in other organisms but also employ unique components including the induction of hypothetical proteins.

Original languageEnglish (US)
Article numbere13655
JournalPLoS One
Volume5
Issue number10
DOIs
StatePublished - 2010

Fingerprint

Treponema denticola
Heat-Shock Proteins
heat shock proteins
stress response
environmental factors
Blood
Hot Temperature
Genes
Hypotonic Solutions
Oxygen
oxygen
Spirochaetales
Proteins
Gene encoding
proteins
blood
Osmotic Pressure
Pathogens
heat stress
transporters

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Transcriptional profiles of Treponema denticola in response to environmental conditions. / Mchardy, Ian Howard; Keegan, Caroline; Sim, Jee Hyun; Shi, Wenyuan; Lux, Renate.

In: PLoS One, Vol. 5, No. 10, e13655, 2010.

Research output: Contribution to journalArticle

Mchardy, Ian Howard ; Keegan, Caroline ; Sim, Jee Hyun ; Shi, Wenyuan ; Lux, Renate. / Transcriptional profiles of Treponema denticola in response to environmental conditions. In: PLoS One. 2010 ; Vol. 5, No. 10.
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