Transcription-replication collisions—a series of unfortunate events

Commodore St Germain, Hongchang Zhao, Jacqueline H. Barlow

Research output: Contribution to journalReview articlepeer-review

Abstract

Transcription-replication interactions occur when DNA replication encounters genomic regions undergoing transcription. Both replication and transcription are essential for life and use the same DNA template making conflicts unavoidable. R-loops, DNA supercoiling, DNA secondary structure, and chromatin-binding proteins are all potential obstacles for processive replication or transcription and pose an even more potent threat to genome integrity when these processes co-occur. It is critical to maintaining high fidelity and processivity of transcription and replication while navigating through a complex chromatin environment, highlighting the importance of defining cellular pathways regulating transcription-replication interaction formation, evasion, and resolution. Here we discuss how transcription influences replication fork stability, and the safeguards that have evolved to navigate transcription-replication interactions and maintain genome integrity in mammalian cells.

Original languageEnglish (US)
Article number1249
JournalBiomolecules
Volume11
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • DNA replication
  • R-loops
  • Replication stress
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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