Transcranial Red and Near Infrared Light Transmission in a Cadaveric Model

Jared Jagdeo, Lauren E. Adams, Neil I. Brody, Daniel M. Siegel

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background and Objective: Low level light therapy has garnered significant interest within the past decade. The exact molecular mechanisms of how red and near infrared light result in physiologic modulation are not fully understood. Heme moieties and copper within cells are red and near infrared light photoreceptors that induce the mitochondrial respiratory chain component cytochrome C oxidase, resulting in a cascade linked to cytoprotection and cellular metabolism. The copper centers in cytochrome C oxidase have a broad absorption range that peaks around 830 nm. Several in vitro and in vivo animal and human models exist that have demonstrated the benefits of red light and near infrared light for various conditions. Clinical applications for low level light therapy are varied. One study in particular demonstrated improved durable functional outcomes status post-stroke in patients treated with near infrared low level light therapy compared to sham treatment [1]. Despite previous data suggesting the beneficial effect in treating multiple conditions, including stroke, with low level light therapy, limited data exists that measures transmission in a human model. Study Design/Materials and Methods: To investigate this idea, we measured the transmission of near infrared light energy, using red light for purposes of comparison, through intact cadaver soft tissue, skull bones, and brain using a commercially available LED device at 830 nm and 633 nm. Results: Our results demonstrate that near infrared measurably penetrates soft tissue, bone and brain parenchyma in the formalin preserved cadaveric model, in comparison to negligible red light transmission in the same conditions. Conclusion: These findings indicate that near infrared light can penetrate formalin fixed soft tissue, bone and brain and implicate that benefits observed in clinical studies are potentially related to direct action of near infrared light on neural tissue.

Original languageEnglish (US)
Article numbere47460
JournalPLoS One
Volume7
Issue number10
DOIs
StatePublished - Oct 15 2012

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Infrared transmission
Light transmission
Light
red light
Infrared radiation
bones
cytochromes
brain
stroke
formalin
copper
Electron Transport Complex IV
Tissue
Bone and Bones
Brain
Bone
Formaldehyde
Copper
electron transport chain
heme

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Transcranial Red and Near Infrared Light Transmission in a Cadaveric Model. / Jagdeo, Jared; Adams, Lauren E.; Brody, Neil I.; Siegel, Daniel M.

In: PLoS One, Vol. 7, No. 10, e47460, 15.10.2012.

Research output: Contribution to journalArticle

Jagdeo, Jared ; Adams, Lauren E. ; Brody, Neil I. ; Siegel, Daniel M. / Transcranial Red and Near Infrared Light Transmission in a Cadaveric Model. In: PLoS One. 2012 ; Vol. 7, No. 10.
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