Transcranial magnetic stimulation of left prefrontal cortex impairs working memory

Brendan R. Mull, Masud Seyal

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Objectives: Several lines of evidence suggest that the prefrontal cortex is involved in working memory. Our goal was to determine whether transient functional disruption of the dorsolateral prefrontal cortex (DLPFC) would impair performance in a sequential-letter working memory task. Methods: Subjects were shown sequences of letters and asked to state whether the letter just displayed was the same as the one presented 3-back. Single-pulse transcranial magnetic stimulation (TMS) was applied over the DLPFC between letter presentations. Results: TMS applied over the left DLPFC resulted in increased errors relative to no TMS controls. TMS over the right DLPFC did not alter working memory performance. Conclusion: Our results indicate that the left prefrontal cortex has a crucial role in at least one type of working memory.

Original languageEnglish (US)
Pages (from-to)1672-1675
Number of pages4
JournalClinical Neurophysiology
Volume112
Issue number9
DOIs
StatePublished - 2001

Fingerprint

Transcranial Magnetic Stimulation
Prefrontal Cortex
Short-Term Memory

Keywords

  • Dorsolateral prefrontal cortex
  • Functional disruption
  • Transcranial magnetic stimulation
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Transcranial magnetic stimulation of left prefrontal cortex impairs working memory. / Mull, Brendan R.; Seyal, Masud.

In: Clinical Neurophysiology, Vol. 112, No. 9, 2001, p. 1672-1675.

Research output: Contribution to journalArticle

@article{e56ee111a4f44f68b385126f12d5f64d,
title = "Transcranial magnetic stimulation of left prefrontal cortex impairs working memory",
abstract = "Objectives: Several lines of evidence suggest that the prefrontal cortex is involved in working memory. Our goal was to determine whether transient functional disruption of the dorsolateral prefrontal cortex (DLPFC) would impair performance in a sequential-letter working memory task. Methods: Subjects were shown sequences of letters and asked to state whether the letter just displayed was the same as the one presented 3-back. Single-pulse transcranial magnetic stimulation (TMS) was applied over the DLPFC between letter presentations. Results: TMS applied over the left DLPFC resulted in increased errors relative to no TMS controls. TMS over the right DLPFC did not alter working memory performance. Conclusion: Our results indicate that the left prefrontal cortex has a crucial role in at least one type of working memory.",
keywords = "Dorsolateral prefrontal cortex, Functional disruption, Transcranial magnetic stimulation, Working memory",
author = "Mull, {Brendan R.} and Masud Seyal",
year = "2001",
doi = "10.1016/S1388-2457(01)00606-X",
language = "English (US)",
volume = "112",
pages = "1672--1675",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "9",

}

TY - JOUR

T1 - Transcranial magnetic stimulation of left prefrontal cortex impairs working memory

AU - Mull, Brendan R.

AU - Seyal, Masud

PY - 2001

Y1 - 2001

N2 - Objectives: Several lines of evidence suggest that the prefrontal cortex is involved in working memory. Our goal was to determine whether transient functional disruption of the dorsolateral prefrontal cortex (DLPFC) would impair performance in a sequential-letter working memory task. Methods: Subjects were shown sequences of letters and asked to state whether the letter just displayed was the same as the one presented 3-back. Single-pulse transcranial magnetic stimulation (TMS) was applied over the DLPFC between letter presentations. Results: TMS applied over the left DLPFC resulted in increased errors relative to no TMS controls. TMS over the right DLPFC did not alter working memory performance. Conclusion: Our results indicate that the left prefrontal cortex has a crucial role in at least one type of working memory.

AB - Objectives: Several lines of evidence suggest that the prefrontal cortex is involved in working memory. Our goal was to determine whether transient functional disruption of the dorsolateral prefrontal cortex (DLPFC) would impair performance in a sequential-letter working memory task. Methods: Subjects were shown sequences of letters and asked to state whether the letter just displayed was the same as the one presented 3-back. Single-pulse transcranial magnetic stimulation (TMS) was applied over the DLPFC between letter presentations. Results: TMS applied over the left DLPFC resulted in increased errors relative to no TMS controls. TMS over the right DLPFC did not alter working memory performance. Conclusion: Our results indicate that the left prefrontal cortex has a crucial role in at least one type of working memory.

KW - Dorsolateral prefrontal cortex

KW - Functional disruption

KW - Transcranial magnetic stimulation

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=0034893415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034893415&partnerID=8YFLogxK

U2 - 10.1016/S1388-2457(01)00606-X

DO - 10.1016/S1388-2457(01)00606-X

M3 - Article

C2 - 11514250

AN - SCOPUS:0034893415

VL - 112

SP - 1672

EP - 1675

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 9

ER -