Transcortical sensory aphasia: Revisited and revised

Dana Boatman, Barry Gordon, John Hart, Ola Selnes, Diana L Miglioretti, Frederick Lenz

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Transcortical sensory aphasia (TSA) is characterized by impaired auditory comprehension with intact repetition and fluent speech. We induced TSA transiently by electrical interference during routine cortical function mapping in six adult seizure patients. For each patient, TSA was associated with multiple posterior cortical sites, including the posterior superior and middle temporal gyri, in classical Wernicke's area. A number of TSA sites were immediately adjacent to sites where Wernicke's aphasia was elicited in the same patients. Phonological decoding of speech sounds was assessed by auditory syllable discrimination and found to be intact at all sites where TSA was induced. At a subset of electrode sites where the pattern of language deficits otherwise resembled TSA, naming and word reading remained intact. Language lateralization testing by intracarotid amobarbital injection showed no evidence of independent right hemisphere language. These results suggest that TSA may result from a one-way disruption between left hemisphere phonology and lexical-semantic processing.

Original languageEnglish (US)
Pages (from-to)1634-1642
Number of pages9
JournalBrain
Volume123
Issue number8
StatePublished - Aug 2000
Externally publishedYes

Fingerprint

Wernicke Aphasia
Language
Amobarbital
Phonetics
Semantics
Reading
Electrodes
Seizures
Injections

Keywords

  • Cortical auditory disorders
  • Transcortical sensory aphasia
  • Wernicke's aphasia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Boatman, D., Gordon, B., Hart, J., Selnes, O., Miglioretti, D. L., & Lenz, F. (2000). Transcortical sensory aphasia: Revisited and revised. Brain, 123(8), 1634-1642.

Transcortical sensory aphasia : Revisited and revised. / Boatman, Dana; Gordon, Barry; Hart, John; Selnes, Ola; Miglioretti, Diana L; Lenz, Frederick.

In: Brain, Vol. 123, No. 8, 08.2000, p. 1634-1642.

Research output: Contribution to journalArticle

Boatman, D, Gordon, B, Hart, J, Selnes, O, Miglioretti, DL & Lenz, F 2000, 'Transcortical sensory aphasia: Revisited and revised', Brain, vol. 123, no. 8, pp. 1634-1642.
Boatman D, Gordon B, Hart J, Selnes O, Miglioretti DL, Lenz F. Transcortical sensory aphasia: Revisited and revised. Brain. 2000 Aug;123(8):1634-1642.
Boatman, Dana ; Gordon, Barry ; Hart, John ; Selnes, Ola ; Miglioretti, Diana L ; Lenz, Frederick. / Transcortical sensory aphasia : Revisited and revised. In: Brain. 2000 ; Vol. 123, No. 8. pp. 1634-1642.
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