Transcallosal effects of a cortical epileptiform focus

Philip A Schwartzkroin, Kin J. Futamachi, Jeffrey L. Noebels, David A. Prince

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Unit activity in anesthetized cats was studied in cortical regions contralateral to the site of an acute epileptiform focus. Orthodromic effects of transcallosal discharge varied in extracellular records; however, in intracellular records, most cells displayed an EPSP-IPSP sequence. In a small proportion of cells, antidromic activation was also observed. The significance of this 'backfiring' phenomenon, and some factors possibly involved in generation of 'backfiring' activity, are discussed.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalBrain Research
Issue number1
StatePublished - Nov 28 1975
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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