Transcallosal effects of a cortical epileptiform focus

Philip A Schwartzkroin, Kin J. Futamachi, Jeffrey L. Noebels, David A. Prince

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Unit activity in anesthetized cats was studied in cortical regions contralateral to the site of an acute epileptiform focus. Orthodromic effects of transcallosal discharge varied in extracellular records; however, in intracellular records, most cells displayed an EPSP-IPSP sequence. In a small proportion of cells, antidromic activation was also observed. The significance of this 'backfiring' phenomenon, and some factors possibly involved in generation of 'backfiring' activity, are discussed.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalBrain Research
Volume99
Issue number1
DOIs
StatePublished - Nov 28 1975
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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