Transarterial wall oxygen gradients at a prosthetic vascular graft to artery anastomosis in the rabbit

Steven M. Santilli, Shane E. Wernsing, Eugene S Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Artery-wall hypoxia has been proposed to contribute to many kinds of artery-wall pathologic conditions, including atherosclerosis and intimal hyperplasia. Intimal hyperplasia is common at sites of arterial injury, including an anastomosis. The purpose of this study was to determine the effect of a prosthetic vascular graft (PVG)-to-artery anastomosis on the delivery of oxygen to the artery wall. Methods: The transarterial wall oxygen gradient in the infrarenal aorta of New Zealand White rabbits 2 mm distal to a PVG-to-artery anastomosis was measured with an oxygen microelectrode. Results: Oxygen tensions were significantly decreased in the outer artery wall immediately after the creation of the anastomosis and showed a further decrease in oxygen tensions at days 7 and 14, which correlated with the absence of a vasa vasorum. After day 14, the oxygen tensions gradually increased, returning to normal by postanastomosis day 42, correlating with a return of the vasa vasorum. These changes were noted without differences in blood pressure or arterial blood oxygen concentrations. Conclusion: The delivery of oxygen to the artery wall is altered by the creation of a PVG-to- artery anastomosis. Low arterial oxygen tensions at a PVG-to-artery anastomosis support a role for artery-wall hypoxia in the formation of intimal hyperplasia at the site of a PVG-to-artery anastomosis.

Original languageEnglish (US)
Pages (from-to)1229-1239
Number of pages11
JournalJournal of Vascular Surgery
Volume31
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

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Blood Vessels
Arteries
Oxygen
Rabbits
Transplants
Tunica Intima
Vasa Vasorum
Hyperplasia
Arterial Pressure
Microelectrodes
Aorta
Atherosclerosis
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Transarterial wall oxygen gradients at a prosthetic vascular graft to artery anastomosis in the rabbit. / Santilli, Steven M.; Wernsing, Shane E.; Lee, Eugene S.

In: Journal of Vascular Surgery, Vol. 31, No. 6, 2000, p. 1229-1239.

Research output: Contribution to journalArticle

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