Trafficking of β-adrenergic receptors: Implications in intracellular receptor signaling

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

β-Adrenergic receptors (βARs), prototypical G-protein-coupled receptors, play a pivotal role in regulating neuronal and cardiovascular responses to catecholamines during stress. Agonist-induced receptor endocytosis is traditionally considered as a primary mechanism to turn off the receptor signaling (or receptor desensitization). However, recent progress suggests that intracellular trafficking of βAR presents a mean to translocate receptor signaling machinery to intracellular organelles/compartments while terminating the signaling at the cell surface. Moreover, the apparent multidimensionality of ligand efficacy in space and time in a cell has forecasted exciting pathophysiological implications, which are just beginning to be explored. As we begin to understand how these pathways impact downstream cellular programs, this will have significant implications for a number of pathophysiological conditions in heart and other systems, that in turn open up new therapeutic opportunities.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier
Pages151-188
Number of pages38
Volume132
ISBN (Print)9780128029398
DOIs
StatePublished - 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume132
ISSN (Print)18771173
ISSN (Electronic)18780814

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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    Fu, Q., & Xiang, Y. K. (2015). Trafficking of β-adrenergic receptors: Implications in intracellular receptor signaling. In Progress in Molecular Biology and Translational Science (Vol. 132, pp. 151-188). (Progress in Molecular Biology and Translational Science; Vol. 132). Elsevier. https://doi.org/10.1016/bs.pmbts.2015.03.008