Abstract
β-Adrenergic receptors (βARs), prototypical G-protein-coupled receptors, play a pivotal role in regulating neuronal and cardiovascular responses to catecholamines during stress. Agonist-induced receptor endocytosis is traditionally considered as a primary mechanism to turn off the receptor signaling (or receptor desensitization). However, recent progress suggests that intracellular trafficking of βAR presents a mean to translocate receptor signaling machinery to intracellular organelles/compartments while terminating the signaling at the cell surface. Moreover, the apparent multidimensionality of ligand efficacy in space and time in a cell has forecasted exciting pathophysiological implications, which are just beginning to be explored. As we begin to understand how these pathways impact downstream cellular programs, this will have significant implications for a number of pathophysiological conditions in heart and other systems, that in turn open up new therapeutic opportunities.
| Original language | English (US) |
|---|---|
| Title of host publication | Progress in Molecular Biology and Translational Science |
| Publisher | Elsevier |
| Pages | 151-188 |
| Number of pages | 38 |
| Volume | 132 |
| ISBN (Print) | 9780128029398 |
| DOIs | |
| State | Published - 2015 |
Publication series
| Name | Progress in Molecular Biology and Translational Science |
|---|---|
| Volume | 132 |
| ISSN (Print) | 18771173 |
| ISSN (Electronic) | 18780814 |
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ASJC Scopus subject areas
- Molecular Biology
- Molecular Medicine
Cite this
Trafficking of β-adrenergic receptors : Implications in intracellular receptor signaling. / Fu, Qin; Xiang, Yang Kevin.
Progress in Molecular Biology and Translational Science. Vol. 132 Elsevier, 2015. p. 151-188 (Progress in Molecular Biology and Translational Science; Vol. 132).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Trafficking of β-adrenergic receptors
T2 - Implications in intracellular receptor signaling
AU - Fu, Qin
AU - Xiang, Yang Kevin
PY - 2015
Y1 - 2015
N2 - β-Adrenergic receptors (βARs), prototypical G-protein-coupled receptors, play a pivotal role in regulating neuronal and cardiovascular responses to catecholamines during stress. Agonist-induced receptor endocytosis is traditionally considered as a primary mechanism to turn off the receptor signaling (or receptor desensitization). However, recent progress suggests that intracellular trafficking of βAR presents a mean to translocate receptor signaling machinery to intracellular organelles/compartments while terminating the signaling at the cell surface. Moreover, the apparent multidimensionality of ligand efficacy in space and time in a cell has forecasted exciting pathophysiological implications, which are just beginning to be explored. As we begin to understand how these pathways impact downstream cellular programs, this will have significant implications for a number of pathophysiological conditions in heart and other systems, that in turn open up new therapeutic opportunities.
AB - β-Adrenergic receptors (βARs), prototypical G-protein-coupled receptors, play a pivotal role in regulating neuronal and cardiovascular responses to catecholamines during stress. Agonist-induced receptor endocytosis is traditionally considered as a primary mechanism to turn off the receptor signaling (or receptor desensitization). However, recent progress suggests that intracellular trafficking of βAR presents a mean to translocate receptor signaling machinery to intracellular organelles/compartments while terminating the signaling at the cell surface. Moreover, the apparent multidimensionality of ligand efficacy in space and time in a cell has forecasted exciting pathophysiological implications, which are just beginning to be explored. As we begin to understand how these pathways impact downstream cellular programs, this will have significant implications for a number of pathophysiological conditions in heart and other systems, that in turn open up new therapeutic opportunities.
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UR - http://www.scopus.com/inward/citedby.url?scp=84946176992&partnerID=8YFLogxK
U2 - 10.1016/bs.pmbts.2015.03.008
DO - 10.1016/bs.pmbts.2015.03.008
M3 - Conference contribution
SN - 9780128029398
VL - 132
T3 - Progress in Molecular Biology and Translational Science
SP - 151
EP - 188
BT - Progress in Molecular Biology and Translational Science
PB - Elsevier
ER -