Traditional breast cancer risk factors in Filipina Americans compared with Chinese and Japanese Americans in Los Angeles county

Anna H. Wu, Cheryl Vigen, Eunjung Lee, Chiu Chen Tseng, Lesley M. Butler

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Filipina Americans have one of the highest breast cancer incidence rates among Asian Americans for poorly understood reasons. Methods: Breast cancer risk factors were investigated in a population-based study of Filipina (790 cases, 587 controls), Japanese (543 cases, 510 controls), and Chinese (913 cases, 904 controls) Americans. Cases were identified by the Los Angeles County Cancer Surveillance Program, and controls were matched to cases on age, ethnicity, and neighborhood. Multivariable conditional logistic regression was performed by Asian ethnicity. Results: In Filipina, Chinese, and Japanese Americans, breast cancer risk decreased significantly with increasing parity (all Ptrend < 0.0001). Breast cancer risk increased with increasing quartiles of cumulative menstrual months in premenopausal (Ptrend=0.019) and postmenopausal Filipina (Ptrend = 0.008), in premenopausal (Ptrend = 0.0003) but not postmenopausal Chinese (Ptrend = 0.79), and in neither premenopausal (Ptrend = 0.092) nor postmenopausal (Ptrend = 0.75) Japanese Americans. For postmenopausal Filipina and Japanese, greater weight gain since age 18 (Ptrend = 0.019 and 0.053, respectively), high current body mass index (both Ptrend < 0.01), and greater waist circumferences (both Ptrend < 0.04) were statistically significant; these associations were weaker for postmenopausal Chinese women. Conclusions: Cumulative menstrual months and body size factors were statistically significant risk factors for Filipina. Total menstrual months were associated with breast cancer among Chinese but not for Japanese, while body size factors were significantly associated with risk among Japanese but not among Chinese. Impact: Characterization of breast cancer risk factors in Filipina will help to generate hypotheses for their high breast cancer incidence.

Original languageEnglish (US)
Pages (from-to)1572-1586
Number of pages15
JournalCancer Epidemiology Biomarkers and Prevention
Volume25
Issue number12
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Fingerprint Dive into the research topics of 'Traditional breast cancer risk factors in Filipina Americans compared with Chinese and Japanese Americans in Los Angeles county'. Together they form a unique fingerprint.

Cite this