Tracking the dynamics of T-cell activation in response to Salmonella infection

Rajesh Ravindran, Stephen J Mcsorley

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T-cell activation and the development of immunological memory during Salmonella infection should lead to the development of more effective prophylactic intervention. Here, we review recent literature on the initiation, expansion and memory development of T-cell responses using the mouse model of typhoid. We pay particular attention to strategies for tracking T-cell responses in vivo and ex vivo, and suggest models to integrate some these studies.

Original languageEnglish (US)
Pages (from-to)450-458
Number of pages9
JournalImmunology
Volume114
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Bacteria
  • Memory
  • Salmonella
  • T cell
  • Vaccination

ASJC Scopus subject areas

  • Immunology

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