Tracking the dynamics of Salmonella specific T cell responses

James J. Moon, Stephen J Mcsorley

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Over the last decade, significant advances have been made in the methodology for studying immune responses in vivo. It is now possible to follow almost every aspect of pathogen-specific immunity using in vivo models that incorporate physiological infectious doses and natural routes of infection. This new ability to study immunity in a relevant physiological context will greatly expand our understanding of the dynamic interplay between host and pathogen. Visualizing the resolution of primary infection and the development of long-term immunological memory should also aid the development of new vaccines and therapeutics for infectious diseases. In this review, we will describe the application of in vivo visualization technology to Salmonella infection, describe our current understanding of Salmonella-specific immunity, and discuss some unanswered questions that remain in this model.

Original languageEnglish (US)
Pages (from-to)179-198
Number of pages20
JournalCurrent Topics in Microbiology and Immunology
Volume334
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

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