Tracking stem cells in tissue-engineered organs using magnetic nanoparticles

Roxanne Hachani, Mark Lowdell, Martin Birchall, Nguyn Thi Kim Thanh

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The use of human stem cells (SCs) in tissue engineering holds promise in revolutionising the treatment of numerous diseases. There is a pressing need to comprehend the distribution, movement and role of SCs once implanted onto scaffolds. Nanotechnology has provided a platform to investigate this through the development of inorganic magnetic nanoparticles (MNPs). MNPs can be used to label and track SCs by magnetic resonance imaging (MRI) since this clinically available imaging modality has high spatial resolution. In this review, we highlight recent applications of iron oxide and gadolinium based MNPs in SC labelling and MRI; and offer novel considerations for their future development.

Original languageEnglish (US)
Pages (from-to)11362-11373
Number of pages12
JournalNanoscale
Volume5
Issue number23
DOIs
StatePublished - Dec 7 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Hachani, R., Lowdell, M., Birchall, M., & Thanh, N. T. K. (2013). Tracking stem cells in tissue-engineered organs using magnetic nanoparticles. Nanoscale, 5(23), 11362-11373. https://doi.org/10.1039/c3nr03861k