Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection

Stephen J Mcsorley, Sarah Asch, Massimo Costalonga, R. Lee Reinhardt, Marc K. Jenkins

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection.

Original languageEnglish (US)
Pages (from-to)365-377
Number of pages13
JournalImmunity
Volume16
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Salmonella
T-Lymphocytes
Infection
Peyer's Patches
Adoptive Transfer
Salmonella Infections
Lymphoid Tissue
Interleukin-2
B-Lymphocytes
Spleen
Bacteria
Liver

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. / Mcsorley, Stephen J; Asch, Sarah; Costalonga, Massimo; Reinhardt, R. Lee; Jenkins, Marc K.

In: Immunity, Vol. 16, No. 3, 2002, p. 365-377.

Research output: Contribution to journalArticle

Mcsorley, Stephen J ; Asch, Sarah ; Costalonga, Massimo ; Reinhardt, R. Lee ; Jenkins, Marc K. / Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. In: Immunity. 2002 ; Vol. 16, No. 3. pp. 365-377.
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