Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection

Stephen J Mcsorley, Sarah Asch, Massimo Costalonga, R. Lee Reinhardt, Marc K. Jenkins

Research output: Contribution to journalArticle

182 Scopus citations

Abstract

A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection.

Original languageEnglish (US)
Pages (from-to)365-377
Number of pages13
JournalImmunity
Volume16
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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