Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI

Xiaodong Zhong, Craig H. Meyer, David J. Schlesinger, Jason P. Sheehan, Frederick H. Epstein, James M. Larner, Stanley H Benedict, Paul W. Read, Ke Sheng, Jing Cai

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Cardiac-synchronized brain motion is well documented, but the accurate measurement of such motion on the pixel-by-pixel basis has been hampered by the lack of proper imaging technique. In this article, the authors present the implementation of an autotracking spiral cine displacement-encoded stimulation echo (DENSE) magnetic resonance imaging (MRI) technique for the measurement of pulsatile brain motion during the cardiac cycle. Displacement-encoded dynamic MR images of three healthy volunteers were acquired throughout the cardiac cycle using the spiral cine-DENSE pulse sequence gated to the R wave of an electrocardiogram. Pixelwise Lagrangian displacement maps were computed, and 2D displacement as a function of time was determined for selected regions of interests. Different intracranial structures exhibited characteristic motion amplitude, direction, and pattern throughout the cardiac cycle. Time-resolved displacement curves revealed the pathway of pulsatile motion from brain stem to peripheral brain lobes. These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity.

Original languageEnglish (US)
Pages (from-to)3413-3419
Number of pages7
JournalMedical Physics
Volume36
Issue number8
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Brain motion
  • DENSE
  • MRI
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI'. Together they form a unique fingerprint.

Cite this