Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI

Xiaodong Zhong, Craig H. Meyer, David J. Schlesinger, Jason P. Sheehan, Frederick H. Epstein, James M. Larner, Stanley H Benedict, Paul W. Read, Ke Sheng, Jing Cai

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Cardiac-synchronized brain motion is well documented, but the accurate measurement of such motion on the pixel-by-pixel basis has been hampered by the lack of proper imaging technique. In this article, the authors present the implementation of an autotracking spiral cine displacement-encoded stimulation echo (DENSE) magnetic resonance imaging (MRI) technique for the measurement of pulsatile brain motion during the cardiac cycle. Displacement-encoded dynamic MR images of three healthy volunteers were acquired throughout the cardiac cycle using the spiral cine-DENSE pulse sequence gated to the R wave of an electrocardiogram. Pixelwise Lagrangian displacement maps were computed, and 2D displacement as a function of time was determined for selected regions of interests. Different intracranial structures exhibited characteristic motion amplitude, direction, and pattern throughout the cardiac cycle. Time-resolved displacement curves revealed the pathway of pulsatile motion from brain stem to peripheral brain lobes. These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity.

Original languageEnglish (US)
Pages (from-to)3413-3419
Number of pages7
JournalMedical Physics
Volume36
Issue number8
DOIs
StatePublished - 2009
Externally publishedYes

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Keywords

  • Brain motion
  • DENSE
  • MRI
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Zhong, X., Meyer, C. H., Schlesinger, D. J., Sheehan, J. P., Epstein, F. H., Larner, J. M., Benedict, S. H., Read, P. W., Sheng, K., & Cai, J. (2009). Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI. Medical Physics, 36(8), 3413-3419. https://doi.org/10.1118/1.3157109